• Characterising the mechanism of DCUN1D1 activity in prostate cancer and identifying DCUN1D1 inhibitors for prostate cancer treatment

  

  Author: Vava, Akhona Date: 2020 DCUN1D1 is an E3 ligase of the neddylation pathway. It mediates the posttranslational modification of majority of the cullin family of proteins with NEDD8. This activity is known to enhance ubiquitination of the cullin RING E3 ligases, however, ... Read more
• Reactive power compensation of fixed speed wind turbines using a hybrid wind turbine technology

  

  Author: Apata, Oluwagbenga Date: 2022 There has been significant growth in the use of wind energy as an alternative form of energy by many countries globally. This is in direct response to calls to reduce environmental pollution from the usage of fossil fuels in energy generation. ... Read more
• Multiscale modelling of sutures in a high-performing biological protective structure: the turtle shell

  

  Author: Alheit, Benjamin Date: 2022 Many natural protective structures, such as alligator armour, turtle shells, and the skulls of many animals including humans, contain networks of sutures; those are, soft tissue that bonds adjacent stiff plates typically made of bone. Such ... Read more
• Investigation of the mechanisms underlying the effects of hyperglycaemia on cardiac structural and electrical remodelling

  

  Author: Aboalgasm, Hamida Date: 2022 Background: Diabetes mellitus with uncontrolled hyperglycaemia is a major cause of cardiovascular complications and mortality. The developing foetal heart in-utero is particularly susceptible to hyperglycaemia through pathological remodelling, ... Read more
• The impact of maternal HIV infection on uninfected neonate brain structure

  

  Author: Ibrahim, Abdulmumin Date: 2022 Successful prevention of mother-to-child HIV transmission (PMTCT) programs have reduced the risk of infant HIV infection in South Africa from 8% in 2008 to an estimated 1.4% in 2015, resulting in an increasing population of HIV-exposed ... Read more
• Young and the urban in Addis Ababa: towards a popular history of the 1974 Ethiopian revolution, c. 1950s-1974

  

  Author: Asfaw, Semeneh Ayalew Date: 2022 This is a study about the Ethiopian revolution through the social and cultural developments that formed the Ethiopian capital, Addis Ababa. The largest participants in the social protests of 1974 were predominantly young Addis Ababans with a ... Read more
• Neurocircuitry of attention in methamphetamine induced psychosis: a comparison against schizophrenia patients and healthy controls

  

  Author: Hsieh, Jennifer Hsin-Wen Date: 2022 Background Methamphetamine induced psychosis (MAP) and schizophrenia present with similar positive symptoms of psychosis, are characterized by evidence of attentional impairment, and show symptomatic response to treatment with dopamine ... Read more
• In pursuit of a panacea: mitigating human-baboon conflict in the Cape Peninsula, South Africa

  

  Author: Kaplan, Bentley Date: 2013 With its unparalleled growth and distribution, the human species is increasingly conflicting with wildlife over crops, livestock and even human life as it infringes on natural habitat. In the Cape Peninsula, South Africa, urbanisation has ... Read more
• Paravalvular sealing pf percutaneous heart valves

  

  Author: Conradie, David Gideon Date: 2019 Paravalvular regurgitation (PVR), which frequently occurs after transcatheter aortic valve replacements (TAVR) can lead to adverse clinical consequences and has been shown to correlate to an increased late mortality and morbidity. Quantification, ... Read more
• Sutured posterior chamber intraocular lenses for traumatic cataract in Africa

  

  Author: Rogers, Graeme J Date: 2013 Ocular trauma is common in low-income countries. Groote Schuur Hospital manages large numbers of patients with the manifestations of ocular trauma every year. The lens and its supporting structures, major refractive components of the eye, may ... Read more
• Selection of bacterial species from wastewater for potential production of poly (γ-glutamic acid): isolation, characterisation and growth kinetics

  

  Author: Madonsela, Ziningi Date: 2013 Wastewater treatment plants represent a source of nutrients for microbial growth and product formation. In an approach in which bioresource productivity is maximised, it is desirable to not only achieve water treatment to the desired standard, ... Read more
• Undocumented and Invisible: Are SADC Member States Implementing the Rights to Birth Registration and Nationality for Migrant Children?

  

  Author: Fortuin, Rowan Victor Date: 2022 The Southern African Development Community sees high levels of migration. Many children within these groups are undocumented and have no means to prove their identities. This greatly increases their risks of statelessness, which opens the way ... Read more
• The role of concentrating solar power in a South African large scale renewable energy scenario

  

  Author: May, Haydn Liam Date: 2014 This thesis investigates a hypothetical large scale renewable energy system for South Africa over the long term future using 2050 as a nominal year of analysis. Simulation modeling was used to assess the integration of three renewable energy ... Read more
• VoIP packet scheduling for LTE advanced

  

  Author: Mugisha, Ronnie Date: 2014 The LTE-A (Long Term Evolution Advanced) technology constitutes a significant step in the evolution of 3G systems towards 4G. The performance targets set out for L TE Advanced make it an ideal solution to take care of the ever-increasing ... Read more
• Geographic range dynamics of South Africa's bird species

  

  Author: Loftie-Eaton, Megan Date: 2014 A key issue in species conservation is a knowledge of the geographic ranges of species, and how these are changing through time. For birds there is a special opportunity to undertake studies of range changes, making use of the data collected ... Read more
• The role of pulmonary innate and adaptive immune responses to helminth infection

  

  Author: Thawer, Sumaiyya G Date: 2014 Immunity to nematode infections requires a host T helper 2 (Th2) response promoted by epithelial cell driven IL-33 induction of cytokine secretion of Interleukin (IL)-4, 5 and 13 by a range of immune cells including innate lymphoid cells type ... Read more
• The role of pulmonary innate and adaptive immune responses to helminth infection

  

  Author: Thawer, Sumaiyya G Date: 2014 Immunity to nematode infections requires a host T helper 2 (Th2) response promoted by epithelial cell driven IL-33 induction of cytokine secretion of Interleukin (IL)-4, 5 and 13 by a range of immune cells including innate lymphoid cells type ... Read more
• Testing for host adaptive evolution using the maize streak virus model

  

  Author: Oyeniran, Kehinde Adewole Date: 2022 Maize streak virus (MSV; Genus: Mastrevirus; Family: Geminiviridae) causes maize streak disease (MSD); a major biotic threat to maize farming especially in sub-Saharan Africa, and it neighbouring Indian and Atlantic Ocean Islands, where its ... Read more
• St John's Wort photomedicine for Melonoma

  

  Author: Kleemann, Britta Date: 2013 The use of photomedicine in ancient civilizations dates back 4000 years ago but it wasn't until the beginning of the 20th century that photodynamic therapy was discovered by man. The “trinity” of photodynamic therapy (PDT) comprises a ... Read more
• Synthesis, characterisation and pharmacological evaluation of silicon-containing aminoquinoline organometallic complexes as antiplasmodial, antitumor and antimycobacterial agents

  

  Author: Li, Yiqun Tony Date: 2013 The medical success of platinum-based compounds such as cisplatin and its analogues laid the foundation for the synthesis and application of new transition metal complexes in the field of medicine. With the discovery of additional transition ... Read more

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