• Characterising the mechanism of DCUN1D1 activity in prostate cancer and identifying DCUN1D1 inhibitors for prostate cancer treatment

  

  Author: Vava, Akhona Date: 2020 DCUN1D1 is an E3 ligase of the neddylation pathway. It mediates the posttranslational modification of majority of the cullin family of proteins with NEDD8. This activity is known to enhance ubiquitination of the cullin RING E3 ligases, however, ... Read more
• Reactive power compensation of fixed speed wind turbines using a hybrid wind turbine technology

  

  Author: Apata, Oluwagbenga Date: 2022 There has been significant growth in the use of wind energy as an alternative form of energy by many countries globally. This is in direct response to calls to reduce environmental pollution from the usage of fossil fuels in energy generation. ... Read more
• Multiscale modelling of sutures in a high-performing biological protective structure: the turtle shell

  

  Author: Alheit, Benjamin Date: 2022 Many natural protective structures, such as alligator armour, turtle shells, and the skulls of many animals including humans, contain networks of sutures; those are, soft tissue that bonds adjacent stiff plates typically made of bone. Such ... Read more
• Investigation of the mechanisms underlying the effects of hyperglycaemia on cardiac structural and electrical remodelling

  

  Author: Aboalgasm, Hamida Date: 2022 Background: Diabetes mellitus with uncontrolled hyperglycaemia is a major cause of cardiovascular complications and mortality. The developing foetal heart in-utero is particularly susceptible to hyperglycaemia through pathological remodelling, ... Read more
• The impact of maternal HIV infection on uninfected neonate brain structure

  

  Author: Ibrahim, Abdulmumin Date: 2022 Successful prevention of mother-to-child HIV transmission (PMTCT) programs have reduced the risk of infant HIV infection in South Africa from 8% in 2008 to an estimated 1.4% in 2015, resulting in an increasing population of HIV-exposed ... Read more

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