Functional consequences of South African mutations of the HIV-1 co-receptor, CCR5
Doctoral Thesis
2007
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University of Cape Town
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Abstract
Four mutations of the CCR5 receptor have been identified in the South African population, but the effects of these mutations on CCR5 function and HIV infection are unknown. We have used in vitro methods to assess the ffect of the mutations, Asp2Val, Leu107Phe, Arg225Gln and Arg225stop, on CCR5 interactions with chemokine ligands and HIV.
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Includes bibliographical references (p. 100-119).
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Folefoc, A. 2007. Functional consequences of South African mutations of the HIV-1 co-receptor, CCR5. University of Cape Town.