Development of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria

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dc.contributor.advisorGammon, David Wen_ZA
dc.contributor.authorKinfe, Henok Hadguen_ZA
dc.date.accessioned2014-08-13T14:26:41Z
dc.date.available2014-08-13T14:26:41Z
dc.date.issued2006en_ZA
dc.descriptionIncludes bibliographical references (p. 177-186).en_ZA
dc.description.abstractTuberculosis (TB) is a contagious respiratory disease caused by Mycobacterium tuberculosis. Due to lack of an efficient and short-term treatment of TB, the bacterium has become resistant to the first line antibiotics and the disease has ranked next to HIV/AIDS. A low molecular weight thiol called myctothiol protects the bacteria from many foreign stress factors and secures its survival. Studies have shown the mycothiol-deficient bacteria are hypersensitive to external stresses and hence inhibition of the biosynthesis of mycothiol could be a drug lead against TB.en_ZA
dc.identifier.apacitationKinfe, H. H. (2006). <i>Development of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/6318en_ZA
dc.identifier.chicagocitationKinfe, Henok Hadgu. <i>"Development of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2006. http://hdl.handle.net/11427/6318en_ZA
dc.identifier.citationKinfe, H. 2006. Development of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Kinfe, Henok Hadgu AB - Tuberculosis (TB) is a contagious respiratory disease caused by Mycobacterium tuberculosis. Due to lack of an efficient and short-term treatment of TB, the bacterium has become resistant to the first line antibiotics and the disease has ranked next to HIV/AIDS. A low molecular weight thiol called myctothiol protects the bacteria from many foreign stress factors and secures its survival. Studies have shown the mycothiol-deficient bacteria are hypersensitive to external stresses and hence inhibition of the biosynthesis of mycothiol could be a drug lead against TB. DA - 2006 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - Development of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria TI - Development of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria UR - http://hdl.handle.net/11427/6318 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/6318
dc.identifier.vancouvercitationKinfe HH. Development of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2006 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6318en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleDevelopment of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteriaen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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