Development of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria
Doctoral Thesis
2006
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University of Cape Town
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Abstract
Tuberculosis (TB) is a contagious respiratory disease caused by Mycobacterium tuberculosis. Due to lack of an efficient and short-term treatment of TB, the bacterium has become resistant to the first line antibiotics and the disease has ranked next to HIV/AIDS. A low molecular weight thiol called myctothiol protects the bacteria from many foreign stress factors and secures its survival. Studies have shown the mycothiol-deficient bacteria are hypersensitive to external stresses and hence inhibition of the biosynthesis of mycothiol could be a drug lead against TB.
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Includes bibliographical references (p. 177-186).
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Kinfe, H. 2006. Development of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria. University of Cape Town.