Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds

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dc.contributor.advisorEgan, Timothy Jen_ZA
dc.contributor.advisorHunter, Rogeren_ZA
dc.contributor.authorKaschula, Catherine Harten_ZA
dc.date.accessioned2014-08-13T14:26:37Z
dc.date.available2014-08-13T14:26:37Z
dc.date.issued2002en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractThe nature of the ferriprotoporphyrin IX (Fe(III)PPIX) antimalarial drug target and its interactions with aminoquinolines was investigated spectrophotometrically. The antiquity of malaria, which is caused by protozoan parasites of the genus Plasmodium, is demonstrated by the host specificity of over 100 parasite species found in reptiles, birds and mammals. The four species of plasmodia that infect man are P. vivax, P. malariae, P. ovale and P. falciparum; of which P. falciparum is the most deadly (Bruce-Chwatt 1981 ).en_ZA
dc.identifier.apacitationKaschula, C. H. (2002). <i>Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/6316en_ZA
dc.identifier.chicagocitationKaschula, Catherine Hart. <i>"Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2002. http://hdl.handle.net/11427/6316en_ZA
dc.identifier.citationKaschula, C. 2002. Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Kaschula, Catherine Hart AB - The nature of the ferriprotoporphyrin IX (Fe(III)PPIX) antimalarial drug target and its interactions with aminoquinolines was investigated spectrophotometrically. The antiquity of malaria, which is caused by protozoan parasites of the genus Plasmodium, is demonstrated by the host specificity of over 100 parasite species found in reptiles, birds and mammals. The four species of plasmodia that infect man are P. vivax, P. malariae, P. ovale and P. falciparum; of which P. falciparum is the most deadly (Bruce-Chwatt 1981 ). DA - 2002 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2002 T1 - Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds TI - Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds UR - http://hdl.handle.net/11427/6316 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/6316
dc.identifier.vancouvercitationKaschula CH. Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2002 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6316en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleHaematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compoundsen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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