Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds

Doctoral Thesis

2002

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http://hdl.handle.net/11427/6316
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thesis_sci_2002_kaschula_c_h (1).pdf (12.53 MB)
Authors
Kaschula, Catherine Hart
Supervisors
Egan, Timothy J
Hunter, Roger
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University of Cape Town

Department
Department of Chemistry
Faculty
Faculty of Science
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Abstract
The nature of the ferriprotoporphyrin IX (Fe(III)PPIX) antimalarial drug target and its interactions with aminoquinolines was investigated spectrophotometrically. The antiquity of malaria, which is caused by protozoan parasites of the genus Plasmodium, is demonstrated by the host specificity of over 100 parasite species found in reptiles, birds and mammals. The four species of plasmodia that infect man are P. vivax, P. malariae, P. ovale and P. falciparum; of which P. falciparum is the most deadly (Bruce-Chwatt 1981 ).
Description

Includes bibliographical references.

Keywords
Chemistry

Reference:

Kaschula, C. 2002. Haematin-Quinoline interactions and structure-activity relationships in the antimalarial chloroquine and related compounds. University of Cape Town.

Collections
PhD / Doctoral