Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer

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dc.contributor.advisorParker, Iqbalen_ZA
dc.contributor.advisorDandara, Colleten_ZA
dc.contributor.authorLi, Dong-Pingen_ZA
dc.date.accessioned2014-07-28T14:55:38Z
dc.date.available2014-07-28T14:55:38Z
dc.date.issued2008en_ZA
dc.descriptionIncludes bibliographical references (leaves 109-130).
dc.description.abstractAlthough the incidence and mortality due to the oesophageal squamous cell carcinoma (OSCC) in Black South Africans is extremely high, very little is known about the aetiology and molecular biology of the disease. In order to make a contribution to the understanding to the causes of this disease we investigated the role of the polymorphisms in the genes coding for the cytochrome P450 (CYP1A1, CYP1A2, CYP1B1, CYP2E1), sulphotransferase 1A1 (SULT1A1), glutathione S-transferases (GSTT1. GSTM1 and GSTP1) alcohol dehydrogenase (ADH2 and ADH3) and aldehyde dehydrogenase (ALDH2) because the products of these genes are involved in the metabolism or biotransformation of harmful compounds.en_ZA
dc.identifier.apacitationLi, D. (2008). <i>Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry. Retrieved from http://hdl.handle.net/11427/3137en_ZA
dc.identifier.chicagocitationLi, Dong-Ping. <i>"Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2008. http://hdl.handle.net/11427/3137en_ZA
dc.identifier.citationLi, D. 2008. Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Li, Dong-Ping AB - Although the incidence and mortality due to the oesophageal squamous cell carcinoma (OSCC) in Black South Africans is extremely high, very little is known about the aetiology and molecular biology of the disease. In order to make a contribution to the understanding to the causes of this disease we investigated the role of the polymorphisms in the genes coding for the cytochrome P450 (CYP1A1, CYP1A2, CYP1B1, CYP2E1), sulphotransferase 1A1 (SULT1A1), glutathione S-transferases (GSTT1. GSTM1 and GSTP1) alcohol dehydrogenase (ADH2 and ADH3) and aldehyde dehydrogenase (ALDH2) because the products of these genes are involved in the metabolism or biotransformation of harmful compounds. DA - 2008 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer TI - Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer UR - http://hdl.handle.net/11427/3137 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3137
dc.identifier.vancouvercitationLi D. Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2008 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3137en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Medical Biochemistryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Biochemistryen_ZA
dc.titleGenetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal canceren_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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