Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer

Doctoral Thesis

2008

Permanent link to this Item
http://hdl.handle.net/11427/3137
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thesis_hsf_2007_maritz_mf.pdf (6.49 MB)
Authors
Li, Dong-Ping
Supervisors
Parker, Iqbal
Dandara, Collet
Journal Title
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Volume Title
Publisher
Publisher

University of Cape Town

Department
Division of Medical Biochemistry
Faculty
Faculty of Health Sciences
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Abstract
Although the incidence and mortality due to the oesophageal squamous cell carcinoma (OSCC) in Black South Africans is extremely high, very little is known about the aetiology and molecular biology of the disease. In order to make a contribution to the understanding to the causes of this disease we investigated the role of the polymorphisms in the genes coding for the cytochrome P450 (CYP1A1, CYP1A2, CYP1B1, CYP2E1), sulphotransferase 1A1 (SULT1A1), glutathione S-transferases (GSTT1. GSTM1 and GSTP1) alcohol dehydrogenase (ADH2 and ADH3) and aldehyde dehydrogenase (ALDH2) because the products of these genes are involved in the metabolism or biotransformation of harmful compounds.
Description

Includes bibliographical references (leaves 109-130).

Keywords
Medical Biochemistry

Reference:

Li, D. 2008. Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer. University of Cape Town.

Collections
PhD / Doctoral