The effect of metronidazole on Bacteroides fragilis and Escherichia coli

Simple item page
dc.contributor.advisorAbratt, Valerie Roseen_ZA
dc.contributor.advisorWoods, David Ren_ZA
dc.contributor.authorDachs, Gabriele Ursulaen_ZA
dc.date.accessioned2016-03-28T14:33:32Z
dc.date.available2016-03-28T14:33:32Z
dc.date.issued1992en_ZA
dc.description.abstractThe antibiotic metronidazole is used extensively in the clinical treatment of anaerobic infections, including those caused by the anaerobic pathogen Bacteroides fragilis. Metronidazole is an inert substance that requires reductive activation to become cytotoxic. In its activated form metronidazole induces DNA damage. Relatively little is known about the cytotoxic effects of this drug in vivo. The aim of the work reported in this thesis was to analyze the mode of action of metronidazole in living systems. Furthermore, the potential for bacterial cells to develop resistance mechanisms to metronidazole is largely unknown, and therefore the role played by B. fragilis genes in influencing the potency of metronidazole was investigated. Bibliography: pages 172-201.en_ZA
dc.identifier.apacitationDachs, G. U. (1992). <i>The effect of metronidazole on Bacteroides fragilis and Escherichia coli</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology. Retrieved from http://hdl.handle.net/11427/18281en_ZA
dc.identifier.chicagocitationDachs, Gabriele Ursula. <i>"The effect of metronidazole on Bacteroides fragilis and Escherichia coli."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 1992. http://hdl.handle.net/11427/18281en_ZA
dc.identifier.citationDachs, G. 1992. The effect of metronidazole on Bacteroides fragilis and Escherichia coli. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Dachs, Gabriele Ursula AB - The antibiotic metronidazole is used extensively in the clinical treatment of anaerobic infections, including those caused by the anaerobic pathogen Bacteroides fragilis. Metronidazole is an inert substance that requires reductive activation to become cytotoxic. In its activated form metronidazole induces DNA damage. Relatively little is known about the cytotoxic effects of this drug in vivo. The aim of the work reported in this thesis was to analyze the mode of action of metronidazole in living systems. Furthermore, the potential for bacterial cells to develop resistance mechanisms to metronidazole is largely unknown, and therefore the role played by B. fragilis genes in influencing the potency of metronidazole was investigated. Bibliography: pages 172-201. DA - 1992 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1992 T1 - The effect of metronidazole on Bacteroides fragilis and Escherichia coli TI - The effect of metronidazole on Bacteroides fragilis and Escherichia coli UR - http://hdl.handle.net/11427/18281 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/18281
dc.identifier.vancouvercitationDachs GU. The effect of metronidazole on Bacteroides fragilis and Escherichia coli. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 1992 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/18281en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Molecular and Cell Biologyen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMolecular and Cell Biologyen_ZA
dc.titleThe effect of metronidazole on Bacteroides fragilis and Escherichia colien_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thesis_sci_1992_dachs_gabriele_ursula (1).pdf
Size:
8.63 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
PhD / Doctoral