The effect of metronidazole on Bacteroides fragilis and Escherichia coli

Doctoral Thesis

1992

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http://hdl.handle.net/11427/18281
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thesis_sci_1992_dachs_gabriele_ursula (1).pdf (8.63 MB)
Authors
Dachs, Gabriele Ursula
Supervisors
Abratt, Valerie Rose
Woods, David R
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University of Cape Town

Department
Department of Molecular and Cell Biology
Faculty
Faculty of Science
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Abstract
The antibiotic metronidazole is used extensively in the clinical treatment of anaerobic infections, including those caused by the anaerobic pathogen Bacteroides fragilis. Metronidazole is an inert substance that requires reductive activation to become cytotoxic. In its activated form metronidazole induces DNA damage. Relatively little is known about the cytotoxic effects of this drug in vivo. The aim of the work reported in this thesis was to analyze the mode of action of metronidazole in living systems. Furthermore, the potential for bacterial cells to develop resistance mechanisms to metronidazole is largely unknown, and therefore the role played by B. fragilis genes in influencing the potency of metronidazole was investigated. Bibliography: pages 172-201.
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Keywords
Molecular and Cell Biology

Reference:

Dachs, G. 1992. The effect of metronidazole on Bacteroides fragilis and Escherichia coli. University of Cape Town.

Collections
PhD / Doctoral