Social trauma and the mu-opioid system in depression
Doctoral Thesis
2011
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University of Cape Town
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Abstract
The overarching thesis under investigation is that the endogenous opioid system plays a key role in depression subsequent to traumatic childhood social experiences. This is suggested by the fact that animal work indicates that mu-opioids robustly mediate separation-distress, and that early social stressors lead to long term dysregulation in key related circuitries and neuroanatomical structures.
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Malcolm-Smith, S. 2011. Social trauma and the mu-opioid system in depression. University of Cape Town.