Insulin, added to nuclei, stimulates transcription of specific genes

Doctoral Thesis

1990

Permanent link to this Item
http://hdl.handle.net/11427/21984
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thesis_sci_1990_stickells_brenda_jane_SR.pdf (2.23 MB)
Authors
Stickells, Brenda Jane
Supervisors
Von Holt, Claus
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University of Cape Town

Department
Department of Molecular and Cell Biology
Faculty
Faculty of Science
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Abstract
Insulin regulates cellular gene expression and modulates specific mRNA levels in liver cells. As yet, the mechanism of this control is still unclear. The effects are initiated following the binding of insulin to the plasma membrane receptor. Although several mediators of the signal from the plasma membrane to the nucleus have been proposed, none has proved capable of eliciting all of the effects of insulin on gene expression. Therefore, the possibility that insulin itself may directly regulate transcription at the level of the nucleus, was investigated.
Description

Bibliography: pages 133-155.

Keywords
Genetic transcription
Insulin

Reference:

Stickells, B. 1990. Insulin, added to nuclei, stimulates transcription of specific genes. University of Cape Town.

Collections
PhD / Doctoral