Radiological progression of lung disease in Human Immunodeficiency Virus (HIV)-infected children

Doctoral Thesis

2016

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http://hdl.handle.net/11427/20351
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thesis_hsf_2016_pitcher_richard_d (1).pdf (1.28 MB)
Authors
Pitcher, Richard D
Supervisors
Zar, Heather
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University of Cape Town

Department
Department of Paediatrics and Child Health
Faculty
Faculty of Health Sciences
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Abstract
Introduction: There are limited data on the chest X-ray (CXR) abnormalities in human immunodeficiency virus (HIV)-infected children in low- and middle-income countries (LMIC's). Aim: To investigate the evolution of CXR abnormalities in HIV-infected children in LMIC's, to correlate this with the severity of HIV-disease, and to assess the impact of anti-retroviral therapy (ART). Method: A prospective longitudinal study evaluating clinical, immunological and radiographic parameters at regular intervals over a minimum of 24 months. CXR abnormalities were stratified by severity and deemed persistent if present for 6 consecutive months or longer. Univariate and multiple logistic regression analyses assessed associations between radiological and clinical/immunological parameters at enrolment. An ordinal multiple logistic regression model assessed the association of enrolment and time-dependent variables with CXR findings over time.
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Keywords
Paediatrics and Child Health

Reference:

Pitcher, R. 2016. Radiological progression of lung disease in Human Immunodeficiency Virus (HIV)-infected children. University of Cape Town.

Collections
PhD / Doctoral