The first-pass extraction of pindolol in comparison with propranolol in rat liver
Master Thesis
1979
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University of Cape Town
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Abstract
Reports in the literature have shown that in man propranolol has a larger first-pass effect (70%) than pindolol (13%). The aim of this research was to make a direct comparison of first-pass extraction and other pharmacokinetic parameters of these drugs under identical experimental conditions by means of an isolated rat liver perfusion model.
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Basset, H. 1979. The first-pass extraction of pindolol in comparison with propranolol in rat liver. University of Cape Town.