The interaction of some halogenated anaesthetic agents with hepatic drug metabolizing enzymes

Simple item page
dc.contributor.advisorIvanetich, Kathrynen_ZA
dc.contributor.authorMarsh, Julia Anneen_ZA
dc.date.accessioned2016-03-21T19:19:24Z
dc.date.available2016-03-21T19:19:24Z
dc.date.issued1977en_ZA
dc.descriptionBibliography: pages 183-200.en_ZA
dc.description.abstractThis thesis comprises a report of investigations into the interaction of the volatile anaesthetic agents, fluroxene, 2,2,2-trifluoroethyl ethyl ether(TFEE), methoxyflurane and enflurane, with hepatic drug metabolizing enzymes in vivo and in vitro. Each of the anaesthetic agents interacts with the type P-450 cytochromes of hepatic microsomes in vitro resulting in the appearance of a type I difference spectrum, enhancement of NADPH oxidation and production of potentially toxic metabolites, 2,2,2-trifluoroethanol (TFE) (from fluroxene and TFEE) and free fluoride ion (from methoxyflurane and enflurane).en_ZA
dc.identifier.apacitationMarsh, J. A. (1977). <i>The interaction of some halogenated anaesthetic agents with hepatic drug metabolizing enzymes</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry. Retrieved from http://hdl.handle.net/11427/18081en_ZA
dc.identifier.chicagocitationMarsh, Julia Anne. <i>"The interaction of some halogenated anaesthetic agents with hepatic drug metabolizing enzymes."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 1977. http://hdl.handle.net/11427/18081en_ZA
dc.identifier.citationMarsh, J. 1977. The interaction of some halogenated anaesthetic agents with hepatic drug metabolizing enzymes. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Marsh, Julia Anne AB - This thesis comprises a report of investigations into the interaction of the volatile anaesthetic agents, fluroxene, 2,2,2-trifluoroethyl ethyl ether(TFEE), methoxyflurane and enflurane, with hepatic drug metabolizing enzymes in vivo and in vitro. Each of the anaesthetic agents interacts with the type P-450 cytochromes of hepatic microsomes in vitro resulting in the appearance of a type I difference spectrum, enhancement of NADPH oxidation and production of potentially toxic metabolites, 2,2,2-trifluoroethanol (TFE) (from fluroxene and TFEE) and free fluoride ion (from methoxyflurane and enflurane). DA - 1977 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1977 T1 - The interaction of some halogenated anaesthetic agents with hepatic drug metabolizing enzymes TI - The interaction of some halogenated anaesthetic agents with hepatic drug metabolizing enzymes UR - http://hdl.handle.net/11427/18081 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/18081
dc.identifier.vancouvercitationMarsh JA. The interaction of some halogenated anaesthetic agents with hepatic drug metabolizing enzymes. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 1977 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/18081en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Medical Biochemistryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Biochemistryen_ZA
dc.titleThe interaction of some halogenated anaesthetic agents with hepatic drug metabolizing enzymesen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thesis_hsf_1977_marsh_julia_anne.pdf
Size:
3.45 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
PhD / Doctoral