The interaction of some halogenated anaesthetic agents with hepatic drug metabolizing enzymes

Doctoral Thesis

1977

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http://hdl.handle.net/11427/18081
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thesis_hsf_1977_marsh_julia_anne.pdf (3.45 MB)
Authors
Marsh, Julia Anne
Supervisors
Ivanetich, Kathryn
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University of Cape Town

Department
Division of Medical Biochemistry
Faculty
Faculty of Health Sciences
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Abstract
This thesis comprises a report of investigations into the interaction of the volatile anaesthetic agents, fluroxene, 2,2,2-trifluoroethyl ethyl ether(TFEE), methoxyflurane and enflurane, with hepatic drug metabolizing enzymes in vivo and in vitro. Each of the anaesthetic agents interacts with the type P-450 cytochromes of hepatic microsomes in vitro resulting in the appearance of a type I difference spectrum, enhancement of NADPH oxidation and production of potentially toxic metabolites, 2,2,2-trifluoroethanol (TFE) (from fluroxene and TFEE) and free fluoride ion (from methoxyflurane and enflurane).
Description

Bibliography: pages 183-200.

Keywords
Medical Biochemistry

Reference:

Marsh, J. 1977. The interaction of some halogenated anaesthetic agents with hepatic drug metabolizing enzymes. University of Cape Town.

Collections
PhD / Doctoral