The role of IL-4Ra during acute schistosomiasis

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dc.contributor.advisorBrombacher, Franken_ZA
dc.contributor.authorLeeto, Mosiuoaen_ZA
dc.date.accessioned2014-07-29T09:06:30Z
dc.date.available2014-07-29T09:06:30Z
dc.date.issued2006en_ZA
dc.descriptionIncludes bibliographical references.
dc.description.abstractDuring an infection with Schistosoma mansoni, immunopathology is associated with a dominant TH-2 type cytokine expression, tissue cosinophilia and high levels of serum immunoglobulin E. It is postulated that in addition to egg specific CD4+T cells, an IL-4Rα+ non-T cell effector population is required to prevent tissue pathology. The role of this dissertation was to examine the functional role of IL-Rα expression on the cells of the myeloid and lymphoid lineages during an acute Schistosoma mansoni infection and its requirement for the extent pf schistosome egg induced lung inflammation and pathology.en_ZA
dc.identifier.apacitationLeeto, M. (2006). <i>The role of IL-4Ra during acute schistosomiasis</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/3416en_ZA
dc.identifier.chicagocitationLeeto, Mosiuoa. <i>"The role of IL-4Ra during acute schistosomiasis."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2006. http://hdl.handle.net/11427/3416en_ZA
dc.identifier.citationLeeto, M. 2006. The role of IL-4Ra during acute schistosomiasis. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Leeto, Mosiuoa AB - During an infection with Schistosoma mansoni, immunopathology is associated with a dominant TH-2 type cytokine expression, tissue cosinophilia and high levels of serum immunoglobulin E. It is postulated that in addition to egg specific CD4+T cells, an IL-4Rα+ non-T cell effector population is required to prevent tissue pathology. The role of this dissertation was to examine the functional role of IL-Rα expression on the cells of the myeloid and lymphoid lineages during an acute Schistosoma mansoni infection and its requirement for the extent pf schistosome egg induced lung inflammation and pathology. DA - 2006 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - The role of IL-4Ra during acute schistosomiasis TI - The role of IL-4Ra during acute schistosomiasis UR - http://hdl.handle.net/11427/3416 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3416
dc.identifier.vancouvercitationLeeto M. The role of IL-4Ra during acute schistosomiasis. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2006 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3416en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleThe role of IL-4Ra during acute schistosomiasisen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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