The role of IL-4Ra during acute schistosomiasis
Doctoral Thesis
2006
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University of Cape Town
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Abstract
During an infection with Schistosoma mansoni, immunopathology is associated with a dominant TH-2 type cytokine expression, tissue cosinophilia and high levels of serum immunoglobulin E. It is postulated that in addition to egg specific CD4+T cells, an IL-4Rα+ non-T cell effector population is required to prevent tissue pathology. The role of this dissertation was to examine the functional role of IL-Rα expression on the cells of the myeloid and lymphoid lineages during an acute Schistosoma mansoni infection and its requirement for the extent pf schistosome egg induced lung inflammation and pathology.
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Includes bibliographical references.
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Leeto, M. 2006. The role of IL-4Ra during acute schistosomiasis. University of Cape Town.