Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine

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dc.contributor.advisorWarren, F Len_ZA
dc.contributor.authorKleynhans, Carl Rudolfen_ZA
dc.date.accessioned2016-03-30T07:11:37Z
dc.date.available2016-03-30T07:11:37Z
dc.date.issued1972en_ZA
dc.description.abstractGerrardine, an alkaloid isolated from Cassipourea gerrardii was previously established as 1-methyl-2,5-bis( 4'-hydroxy-1',2'-dithiolan-3'-yl)-pyrrolidine. The aim of the present research was to study the ways in which 1-methyl-2-(4'-hydroxy-1', 2'-dithiolan-3'-yl)-pyrrolidine, as a model compound could be synthesised since it contained asymmetric centres corresponding to those of gerrardine. The work resolved itself into attempts at the synthesis of 3-(1'-methylpyrrolidin-2'-yl)-1,3-dithiolpropan-2-ol since this would be converted into the required dithiolane by mild oxidation.en_ZA
dc.identifier.apacitationKleynhans, C. R. (1972). <i>Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/18379en_ZA
dc.identifier.chicagocitationKleynhans, Carl Rudolf. <i>"Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 1972. http://hdl.handle.net/11427/18379en_ZA
dc.identifier.citationKleynhans, C. 1972. Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Kleynhans, Carl Rudolf AB - Gerrardine, an alkaloid isolated from Cassipourea gerrardii was previously established as 1-methyl-2,5-bis( 4'-hydroxy-1',2'-dithiolan-3'-yl)-pyrrolidine. The aim of the present research was to study the ways in which 1-methyl-2-(4'-hydroxy-1', 2'-dithiolan-3'-yl)-pyrrolidine, as a model compound could be synthesised since it contained asymmetric centres corresponding to those of gerrardine. The work resolved itself into attempts at the synthesis of 3-(1'-methylpyrrolidin-2'-yl)-1,3-dithiolpropan-2-ol since this would be converted into the required dithiolane by mild oxidation. DA - 1972 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1972 T1 - Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine TI - Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine UR - http://hdl.handle.net/11427/18379 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/18379
dc.identifier.vancouvercitationKleynhans CR. Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 1972 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/18379en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleRhizophoraceae alkaloids : studies in the synthesis of Gerrardineen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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