Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine
Doctoral Thesis
1972
Permanent link to this Item
Authors
Supervisors
Journal Title
Link to Journal
Journal ISSN
Volume Title
Publisher
Publisher
University of Cape Town
Department
Faculty
License
Series
Abstract
Gerrardine, an alkaloid isolated from Cassipourea gerrardii was previously established as 1-methyl-2,5-bis( 4'-hydroxy-1',2'-dithiolan-3'-yl)-pyrrolidine. The aim of the present research was to study the ways in which 1-methyl-2-(4'-hydroxy-1', 2'-dithiolan-3'-yl)-pyrrolidine, as a model compound could be synthesised since it contained asymmetric centres corresponding to those of gerrardine. The work resolved itself into attempts at the synthesis of 3-(1'-methylpyrrolidin-2'-yl)-1,3-dithiolpropan-2-ol since this would be converted into the required dithiolane by mild oxidation.
Description
Keywords
Reference:
Kleynhans, C. 1972. Rhizophoraceae alkaloids : studies in the synthesis of Gerrardine. University of Cape Town.