Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy

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dc.contributor.advisorEssop, M Faadielen_ZA
dc.contributor.authorZungu, Makhosazaneen_ZA
dc.date.accessioned2014-07-29T09:38:49Z
dc.date.available2014-07-29T09:38:49Z
dc.date.issued2007en_ZA
dc.descriptionIncludes bibliographical references.
dc.description.abstractThe major finding of this part of the study is that in vivo Wy-14,643 admnistration elicited direct effects on mitochondrial respiratory function and cardiac contractility. The data show that Wy-14,643 treatment attenuated mitochondrial respiration (state 3 respiration and rate of ADP phosphorylation) in the RV while promoting uncoupling of mitochondrial oxidative phosphorylation (increased state 4 respiration and basal leak) in the LV.en_ZA
dc.identifier.apacitationZungu, M. (2007). <i>Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/3498en_ZA
dc.identifier.chicagocitationZungu, Makhosazane. <i>"Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2007. http://hdl.handle.net/11427/3498en_ZA
dc.identifier.citationZungu, M. 2007. Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Zungu, Makhosazane AB - The major finding of this part of the study is that in vivo Wy-14,643 admnistration elicited direct effects on mitochondrial respiratory function and cardiac contractility. The data show that Wy-14,643 treatment attenuated mitochondrial respiration (state 3 respiration and rate of ADP phosphorylation) in the RV while promoting uncoupling of mitochondrial oxidative phosphorylation (increased state 4 respiration and basal leak) in the LV. DA - 2007 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2007 T1 - Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy TI - Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy UR - http://hdl.handle.net/11427/3498 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3498
dc.identifier.vancouvercitationZungu M. Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2007 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3498en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleCharacterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophyen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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