Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy
Doctoral Thesis
2007
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University of Cape Town
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Abstract
The major finding of this part of the study is that in vivo Wy-14,643 admnistration elicited direct effects on mitochondrial respiratory function and cardiac contractility. The data show that Wy-14,643 treatment attenuated mitochondrial respiration (state 3 respiration and rate of ADP phosphorylation) in the RV while promoting uncoupling of mitochondrial oxidative phosphorylation (increased state 4 respiration and basal leak) in the LV.
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Includes bibliographical references.
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Zungu, M. 2007. Characterization of molecular and functional changes regulating hypobaric hypoxia-induced right ventricular hypertrophy. University of Cape Town.