The glucocorticoid receptor plays a central role in mammalian reproduction and signal integration in pituitary gonadotropes

Doctoral Thesis

2015

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University of Cape Town

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Abstract
Reciprocal modulation between the glucocorticoid receptor (GR) and gonadotropin-releasing hormone (GnRH) signalling pathways is a potential mechanism for integrating cellular responses to stress with reproductive function. This study investigated if membrane rafts play a role in GR and GnRH receptor (GnRHR) crosstalk and explored the mechanism involved in the mouse pituitary gonadotrope LβT2 cell line by dexamethasone (Dex), GnRH and both together.
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