The glucocorticoid receptor plays a central role in mammalian reproduction and signal integration in pituitary gonadotropes

Doctoral Thesis

2015

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http://hdl.handle.net/11427/16934
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thesis_sci_2015_wehmeyer_lance.pdf (3.66 MB)
Authors
Wehmeyer, Lance
Supervisors
Hapgood, Janet P
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University of Cape Town

Department
Department of English Language and Literature
Faculty
Faculty of Humanities
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Abstract
Reciprocal modulation between the glucocorticoid receptor (GR) and gonadotropin-releasing hormone (GnRH) signalling pathways is a potential mechanism for integrating cellular responses to stress with reproductive function. This study investigated if membrane rafts play a role in GR and GnRH receptor (GnRHR) crosstalk and explored the mechanism involved in the mouse pituitary gonadotrope LβT2 cell line by dexamethasone (Dex), GnRH and both together.
Description

Includes bibliographical references

Keywords
Molecular and Cell Biology

Reference:

Wehmeyer, L. 2015. The glucocorticoid receptor plays a central role in mammalian reproduction and signal integration in pituitary gonadotropes. University of Cape Town.

Collections
PhD / Doctoral