Development of candidate Human papillomavirus vaccines

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dc.contributor.advisorRybicki, Eden_ZA
dc.contributor.advisorWilliamson, Anne-Liseen_ZA
dc.contributor.authorVarsani, Arvinden_ZA
dc.date.accessioned2014-08-02T14:56:43Z
dc.date.available2014-08-02T14:56:43Z
dc.date.issued2003en_ZA
dc.descriptionBibliography: leaves 180-218.
dc.description.abstractThe objective of this thesis was to investigate novel and plant-based vaccines against the Human papillomavirus type 16 (HPV-16), which is primarily responsible for cervical cancer. As a first study, the L1 gene of a South Africna variant of HPV-16 (L1 504) and a mutant (504[ΔA266T]), where the alanine at 266 was mutated to a threonine, were expressed in insect cells by recombinant baculovirus, and the resulting virus-like particles (VLPs) were tested with a panel of well-characterised monoclonal antibodies (Mabs).en_ZA
dc.identifier.apacitationVarsani, A. (2003). <i>Development of candidate Human papillomavirus vaccines</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology. Retrieved from http://hdl.handle.net/11427/5970en_ZA
dc.identifier.chicagocitationVarsani, Arvind. <i>"Development of candidate Human papillomavirus vaccines."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2003. http://hdl.handle.net/11427/5970en_ZA
dc.identifier.citationVarsani, A. 2003. Development of candidate Human papillomavirus vaccines. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Varsani, Arvind AB - The objective of this thesis was to investigate novel and plant-based vaccines against the Human papillomavirus type 16 (HPV-16), which is primarily responsible for cervical cancer. As a first study, the L1 gene of a South Africna variant of HPV-16 (L1 504) and a mutant (504[ΔA266T]), where the alanine at 266 was mutated to a threonine, were expressed in insect cells by recombinant baculovirus, and the resulting virus-like particles (VLPs) were tested with a panel of well-characterised monoclonal antibodies (Mabs). DA - 2003 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2003 T1 - Development of candidate Human papillomavirus vaccines TI - Development of candidate Human papillomavirus vaccines UR - http://hdl.handle.net/11427/5970 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/5970
dc.identifier.vancouvercitationVarsani A. Development of candidate Human papillomavirus vaccines. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2003 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/5970en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Molecular and Cell Biologyen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherCell Biologyen_ZA
dc.titleDevelopment of candidate Human papillomavirus vaccinesen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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