Development of candidate Human papillomavirus vaccines

Doctoral Thesis

2003

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http://hdl.handle.net/11427/5970
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thesis_sci_2003_varsani_a (1).pdf (16.85 MB)
Authors
Varsani, Arvind
Supervisors
Rybicki, Ed
Williamson, Anne-Lise
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University of Cape Town

Department
Department of Molecular and Cell Biology
Faculty
Faculty of Science
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Abstract
The objective of this thesis was to investigate novel and plant-based vaccines against the Human papillomavirus type 16 (HPV-16), which is primarily responsible for cervical cancer. As a first study, the L1 gene of a South Africna variant of HPV-16 (L1 504) and a mutant (504[ΔA266T]), where the alanine at 266 was mutated to a threonine, were expressed in insect cells by recombinant baculovirus, and the resulting virus-like particles (VLPs) were tested with a panel of well-characterised monoclonal antibodies (Mabs).
Description

Bibliography: leaves 180-218.

Keywords
Cell Biology

Reference:

Varsani, A. 2003. Development of candidate Human papillomavirus vaccines. University of Cape Town.

Collections
PhD / Doctoral