The role of TNFRp55 and TNFRp75 in the host immune response to Mycobacterium tuberculosis

Doctoral Thesis

2009

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University of Cape Town

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Abstract
Tumor necrosis factor alpha (TNFα) is critical for host protective immunity against Mycobacterium tuberculosis infection. TNFRp55 and TNFRp75 can both bind TNFα and conduct signaling, however the respective roles, in particular that of TNFRp75 in an M. tuberculosis aerosol inhalation infection was poorly defined. In this study the role of signaling through TNFRp55 and TNFRp75 was investigated using TNFR deficient mice in an aerosol inhalation M. tuberculosis infection model.
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Includes bibliographical references (leaves 85-97).

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