L-arginine overproduction in Corynebacterium glutamicum ATCC 13032

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dc.contributor.advisorReid, Sharon Jen_ZA
dc.contributor.authorTheron, Grant de Ven_ZA
dc.date.accessioned2015-01-13T03:59:24Z
dc.date.available2015-01-13T03:59:24Z
dc.date.issued2009en_ZA
dc.descriptionIncludes abstract.en_ZA
dc.descriptionIncludes bibliographical references (p. 155-174).en_ZA
dc.description.abstractCorynebacterium glutamicum is widely used for the commercial production of a variety of amino acids, including L-lysine, L-glutamate and L-threonine. With the exception of Larginine, the biosynthesis and regulation of most of these compounds in this bacterium are relatively well characterised in the literature. The research presented here focuses on improving our understanding of the regulation of L-arginine biosynthesis in C. glutamicum. This was performed with the ultimate goal of creating strains capable of producing L-arginine commercially. A novel gene replacement system was initially used for the directed mutation of the Larginine biosynthetic gene cluster in C. glutamicum ATCC 13032. This was met with limited success, however, and the pK19mobsacB vector was thus adopted for further mutagenesis of this region.en_ZA
dc.identifier.apacitationTheron, G. d. V. (2009). <i>L-arginine overproduction in Corynebacterium glutamicum ATCC 13032</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology. Retrieved from http://hdl.handle.net/11427/12122en_ZA
dc.identifier.chicagocitationTheron, Grant de V. <i>"L-arginine overproduction in Corynebacterium glutamicum ATCC 13032."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2009. http://hdl.handle.net/11427/12122en_ZA
dc.identifier.citationTheron, G. 2009. L-arginine overproduction in Corynebacterium glutamicum ATCC 13032. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Theron, Grant de V AB - Corynebacterium glutamicum is widely used for the commercial production of a variety of amino acids, including L-lysine, L-glutamate and L-threonine. With the exception of Larginine, the biosynthesis and regulation of most of these compounds in this bacterium are relatively well characterised in the literature. The research presented here focuses on improving our understanding of the regulation of L-arginine biosynthesis in C. glutamicum. This was performed with the ultimate goal of creating strains capable of producing L-arginine commercially. A novel gene replacement system was initially used for the directed mutation of the Larginine biosynthetic gene cluster in C. glutamicum ATCC 13032. This was met with limited success, however, and the pK19mobsacB vector was thus adopted for further mutagenesis of this region. DA - 2009 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - L-arginine overproduction in Corynebacterium glutamicum ATCC 13032 TI - L-arginine overproduction in Corynebacterium glutamicum ATCC 13032 UR - http://hdl.handle.net/11427/12122 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/12122
dc.identifier.vancouvercitationTheron GdV. L-arginine overproduction in Corynebacterium glutamicum ATCC 13032. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2009 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12122en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Molecular and Cell Biologyen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherCell Biologyen_ZA
dc.titleL-arginine overproduction in Corynebacterium glutamicum ATCC 13032en_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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