Evolutionary analyses of HIV-1 protein-coding sequences : adaptation to host cytotoxic immune responses and purifying selection at synonymous sites
Doctoral Thesis
2009
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University of Cape Town
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Abstract
This thesis exposes previously ignored evolutionary characteristics of the synonymous sites of virus nucleotide sequences and contributes new findings to the understanding of the evolution of HIV-1 in relation to the human immune response.
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Includes abstract.
Includes bibliographical references (p. 136-165).
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Ngandu, N. 2009. Evolutionary analyses of HIV-1 protein-coding sequences : adaptation to host cytotoxic immune responses and purifying selection at synonymous sites. University of Cape Town.