Molecular mechanism of action of tyrocidine antimicrobial peptides using NMR spectroscopy and computational techniques

Doctoral Thesis

2012

Permanent link to this Item
http://hdl.handle.net/11427/6347
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thesis_sci_2012_munyiki_g.pdf (40.95 MB)
Authors
Munyuki, Gadzikano
Supervisors
Jackson, Graham Ellis
Venter, Gerhard
Journal Title
Link to Journal
Journal ISSN
Volume Title
Publisher
Publisher

University of Cape Town

Department
Department of Chemistry
Faculty
Faculty of Science
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Abstract
The need to come up with new and novel antibiotics that utilize unique mechanisms, to which bacteria cannot generate resistance, was the main motivation of this study. Tyrocidine peptides are non-selective antibiotics that have such properties. However, very limited information is available about their mechanism of action. The aim of this study was to determine the mechanism of action of tyrocidine peptides, tyrocidine A, tyrocidine B and tyrocidine C.
Description

Includes abstract.


Includes bibliographical references.

Keywords
Chemistry

Reference:

Munyuki, G. 2012. Molecular mechanism of action of tyrocidine antimicrobial peptides using NMR spectroscopy and computational techniques. University of Cape Town.

Collections
PhD / Doctoral