Browsing by Author "Kinfe, Henok Hadgu"
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- ItemOpen AccessDevelopment of new methodologies for functionalizing glycals and 1,2-cyclopropanated sugars, and applications in the synthesis of inhibitors of enzymes in the Mycobacteria(2006) Kinfe, Henok Hadgu; Gammon, David WTuberculosis (TB) is a contagious respiratory disease caused by Mycobacterium tuberculosis. Due to lack of an efficient and short-term treatment of TB, the bacterium has become resistant to the first line antibiotics and the disease has ranked next to HIV/AIDS. A low molecular weight thiol called myctothiol protects the bacteria from many foreign stress factors and secures its survival. Studies have shown the mycothiol-deficient bacteria are hypersensitive to external stresses and hence inhibition of the biosynthesis of mycothiol could be a drug lead against TB.
- ItemOpen AccessProgress in the synthesis of stabilized glycoconjugate vaccine candidates against Neisseria meningitides group A(2003) Kinfe, Henok Hadgu; Gammon, David W; Ravenscroft, NeilMeningitis is the inflammation of the lining membranes of human brains and spinal cord. It is a deadly disease that has claimed millions of lives throughout the world in particular in developing countries. Neisseria meningitidis serogroup A is among the leading causative agents of meningitis in Sub-Saharan Africa. Its capsular polysaccharide antigen consists of a homopolymer of a-(1