The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum

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dc.contributor.advisorEgan, Timothy Jen_ZA
dc.contributor.advisorSmith, Peteren_ZA
dc.contributor.authorCombrinck, Jill Michelleen_ZA
dc.date.accessioned2017-01-17T12:23:31Z
dc.date.available2017-01-17T12:23:31Z
dc.date.issued2016en_ZA
dc.description.abstractThe malaria parasite detoxifies host red blood cell derived haem by conversion into the inert biocrystal haemozoin. Inhibiting this critical pathway is proposed to be the mechanism of action of chloroquine and related antimalarials and several studies have linked inhibition of the formation of synthetic haemozoin, β-haematin, to parasite survival. However, haemozoin inhibition with a dose related increase in "free" haem correlated to decreased survival has not been demonstrated in the parasite. This project investigated the role of haem in the mechanism of action of several clinically relevant and novel antimalarials in the malaria parasite, Plasmodium falciparum.en_ZA
dc.identifier.apacitationCombrinck, J. M. (2016). <i>The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology. Retrieved from http://hdl.handle.net/11427/22760en_ZA
dc.identifier.chicagocitationCombrinck, Jill Michelle. <i>"The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 2016. http://hdl.handle.net/11427/22760en_ZA
dc.identifier.citationCombrinck, J. 2016. The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Combrinck, Jill Michelle AB - The malaria parasite detoxifies host red blood cell derived haem by conversion into the inert biocrystal haemozoin. Inhibiting this critical pathway is proposed to be the mechanism of action of chloroquine and related antimalarials and several studies have linked inhibition of the formation of synthetic haemozoin, β-haematin, to parasite survival. However, haemozoin inhibition with a dose related increase in "free" haem correlated to decreased survival has not been demonstrated in the parasite. This project investigated the role of haem in the mechanism of action of several clinically relevant and novel antimalarials in the malaria parasite, Plasmodium falciparum. DA - 2016 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum TI - The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum UR - http://hdl.handle.net/11427/22760 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/22760
dc.identifier.vancouvercitationCombrinck JM. The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 2016 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/22760en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Clinical Pharmacologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPharmacologyen_ZA
dc.titleThe role of haem in the mechanism of action of antimalarials in Plasmodium falciparumen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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