Evidence of ancient papillomavirus recombination

Journal Article

2006

Permanent link to this Item
http://hdl.handle.net/11427/20893
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Varsani_Evidence_ancient_2006.pdf (231.33 KB)
Authors
Varsani, Arvind
van der Walt, Eric
Heath, Livio
Rybicki, Edward P
Williamson, Anna Lise
Martin, Darren P
Journal Title

Journal of General Virology

Link to Journal
http://jgv.microbiologyresearch.org/content/journal/jgv
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Volume Title
Publisher

Microbiology Society

Publisher

University of Cape Town

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Abstract
An open question amongst papillomavirus taxonomists is whether recombination has featured in the evolutionary history of these viruses. Since the onset of the global AIDS epidemic, the question is somewhat less academic, because immune-compromised human immunodeficiency virus patients are often co-infected with extraordinarily diverse mixtures of human papillomavirus (HPV) types. It is expected that these conditions may facilitate the emergence of HPV recombinants, some of which might have novel pathogenic properties. Here, a range of rigorous analyses is applied to full-genome sequences of papillomaviruses to provide convincing statistical and phylogenetic evidence that evolutionarily relevant papillomavirus recombination can occur.
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Reference:

Varsani, A., van der Walt, E., Heath, L., Rybicki, E. P., Williamson, A. L., & Martin, D. P. (2006). Evidence of ancient papillomavirus recombination. Journal of general virology, 87(9), 2527-2531.

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