Exercise-induced protection against insulin resistance and type 11 diabetes : the role of calcium

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dc.contributor.advisorOjuka, Edwarden_ZA
dc.contributor.advisorCollins, Malcolmen_ZA
dc.contributor.authorSmith, James Antony Harrisen_ZA
dc.date.accessioned2014-07-28T08:23:53Z
dc.date.available2014-07-28T08:23:53Z
dc.date.issued2008en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references (p. 89-106).
dc.description.abstractRegular exercise protects individuals against developing insulin resistance and type II diabetes. This effect of exercise does not appear to be due to an improvement in the insulin signalling pathway but instead due to an increase in the content of the insulin-regulatable glucose transporter (GLUT4) in skeletal muscle (84). Understanding the mechanisms by which exercise increases GLUT4 levels in skeletal muscle may reveal targets for pharmaceuticals to treat insulin resistance and type II diabetes. Although in vitro binding assays have shown that GLUT4 expression during exercise is mediated by the binding of myocyte enhancer factor-2A (MEF2A) to its cis-element on the Glut4 promoter (122), this has not been demonstrated in vivo. Moreover, the mechanisms by which exercise increases MEF2A binding to the Glut4 promoter have not been fully characterised.en_ZA
dc.identifier.apacitationSmith, J. A. H. (2008). <i>Exercise-induced protection against insulin resistance and type 11 diabetes : the role of calcium</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,MRC/UCT RU for Exercise and Sport Medicine. Retrieved from http://hdl.handle.net/11427/2767en_ZA
dc.identifier.chicagocitationSmith, James Antony Harris. <i>"Exercise-induced protection against insulin resistance and type 11 diabetes : the role of calcium."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,MRC/UCT RU for Exercise and Sport Medicine, 2008. http://hdl.handle.net/11427/2767en_ZA
dc.identifier.citationSmith, J. 2008. Exercise-induced protection against insulin resistance and type 11 diabetes : the role of calcium. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Smith, James Antony Harris AB - Regular exercise protects individuals against developing insulin resistance and type II diabetes. This effect of exercise does not appear to be due to an improvement in the insulin signalling pathway but instead due to an increase in the content of the insulin-regulatable glucose transporter (GLUT4) in skeletal muscle (84). Understanding the mechanisms by which exercise increases GLUT4 levels in skeletal muscle may reveal targets for pharmaceuticals to treat insulin resistance and type II diabetes. Although in vitro binding assays have shown that GLUT4 expression during exercise is mediated by the binding of myocyte enhancer factor-2A (MEF2A) to its cis-element on the Glut4 promoter (122), this has not been demonstrated in vivo. Moreover, the mechanisms by which exercise increases MEF2A binding to the Glut4 promoter have not been fully characterised. DA - 2008 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - Exercise-induced protection against insulin resistance and type 11 diabetes : the role of calcium TI - Exercise-induced protection against insulin resistance and type 11 diabetes : the role of calcium UR - http://hdl.handle.net/11427/2767 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/2767
dc.identifier.vancouvercitationSmith JAH. Exercise-induced protection against insulin resistance and type 11 diabetes : the role of calcium. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,MRC/UCT RU for Exercise and Sport Medicine, 2008 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/2767en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentMRC/UCT RU for Exercise and Sport Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherExercise Scienceen_ZA
dc.titleExercise-induced protection against insulin resistance and type 11 diabetes : the role of calciumen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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