Genetic factors associated with performance and exercise-associated weight loss in Ironman triathletes

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dc.contributor.advisorCollins, Malcolmen_ZA
dc.contributor.authorDe Milander, Lieslen_ZA
dc.date.accessioned2014-12-28T14:54:32Z
dc.date.available2014-12-28T14:54:32Z
dc.date.issued2012en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractThe aim of this thesis was to investigate candidate genes, mainly within the CNS, that may contribute to the variation in physiological responses (body weight changes) and athletic ability between athletes during participation in a 226 km Ironman triathlon. A genetic association approach was used in case-control studies to identify specific sequence variants within selected candidate genes. These candidate genes (IL-6, 5-HTT and MAO-A) were selected based on the biological function of their encoded proteins, which have been implicated in peripheral and central fatigue models. Candidate genes (5-HTT and AVPR2) that encode for proteins that play key roles in the neuro-endocrine control of total body water homeostasis were also investigated in this thesis.en_ZA
dc.identifier.apacitationDe Milander, L. (2012). <i>Genetic factors associated with performance and exercise-associated weight loss in Ironman triathletes</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/10372en_ZA
dc.identifier.chicagocitationDe Milander, Liesl. <i>"Genetic factors associated with performance and exercise-associated weight loss in Ironman triathletes."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2012. http://hdl.handle.net/11427/10372en_ZA
dc.identifier.citationDe Milander, L. 2012. Genetic factors associated with performance and exercise-associated weight loss in Ironman triathletes. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - De Milander, Liesl AB - The aim of this thesis was to investigate candidate genes, mainly within the CNS, that may contribute to the variation in physiological responses (body weight changes) and athletic ability between athletes during participation in a 226 km Ironman triathlon. A genetic association approach was used in case-control studies to identify specific sequence variants within selected candidate genes. These candidate genes (IL-6, 5-HTT and MAO-A) were selected based on the biological function of their encoded proteins, which have been implicated in peripheral and central fatigue models. Candidate genes (5-HTT and AVPR2) that encode for proteins that play key roles in the neuro-endocrine control of total body water homeostasis were also investigated in this thesis. DA - 2012 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - Genetic factors associated with performance and exercise-associated weight loss in Ironman triathletes TI - Genetic factors associated with performance and exercise-associated weight loss in Ironman triathletes UR - http://hdl.handle.net/11427/10372 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/10372
dc.identifier.vancouvercitationDe Milander L. Genetic factors associated with performance and exercise-associated weight loss in Ironman triathletes. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2012 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/10372en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Human Biologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherHuman Biologyen_ZA
dc.titleGenetic factors associated with performance and exercise-associated weight loss in Ironman triathletesen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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