Control mechanisms of mammalian pepsinogen secretion

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dc.contributor.advisorMarks, Sen_ZA
dc.contributor.authorModlin, Irvin Men_ZA
dc.date.accessioned2018-01-31T13:46:48Z
dc.date.available2018-01-31T13:46:48Z
dc.date.issued1989en_ZA
dc.description.abstractThe objective of this thesis was to delineate aspects of the control mechanisms of mammalian pepsinogen secretion. In order to accomplish this goal, a comprehensive study was undertaken which would establish an historical perspective of the subject, validate appropriate methodology and then seek to answer specific questions regarding the physiology and pathophysiology of pepsinogen secretion. More specifically, the objectives of this thesis were: 1. To review the historical background of the subject of pepsinogen in the context of the physiology of digestion with specific emphasis on the work and lives of the two major initial proponents of pepsinogen research (Schwann and Langley). 2. To provide a contemporary overview and evaluation of the current status of pepsinogen pathophysiology. 3. To modify and adapt experimental models necessary for the study of pepsinogen and acid secretion in mammalian gastric mucosa and cells. 4. To establish and validate a pepsinogen assay sensitive and reproducible enough for use in mammalian mucosa! and cellular secretory systems. 5. To delineate the fundamental (second messenger) control mechanisms (cyclic AMP and calcium calmodulin) of pepsinogen secretion in the isolated gastric gland model. 6. To define whether the process of pepsinogen secretion is independent of acid secretion in intact mucosa! preparations. 7. To identify different classes of pharmacological agents which would inhibit pepsinogen secretion and/or release. 8. To identify whether conditions present in critically ill patients liable to mucosal "stress ulceration" might influence the release of pepsinogen.en_ZA
dc.identifier.apacitationModlin, I. M. (1989). <i>Control mechanisms of mammalian pepsinogen secretion</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Surgical Gastroenterology. Retrieved from http://hdl.handle.net/11427/27173en_ZA
dc.identifier.chicagocitationModlin, Irvin M. <i>"Control mechanisms of mammalian pepsinogen secretion."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Surgical Gastroenterology, 1989. http://hdl.handle.net/11427/27173en_ZA
dc.identifier.citationModlin, I. 1989. Control mechanisms of mammalian pepsinogen secretion. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Modlin, Irvin M AB - The objective of this thesis was to delineate aspects of the control mechanisms of mammalian pepsinogen secretion. In order to accomplish this goal, a comprehensive study was undertaken which would establish an historical perspective of the subject, validate appropriate methodology and then seek to answer specific questions regarding the physiology and pathophysiology of pepsinogen secretion. More specifically, the objectives of this thesis were: 1. To review the historical background of the subject of pepsinogen in the context of the physiology of digestion with specific emphasis on the work and lives of the two major initial proponents of pepsinogen research (Schwann and Langley). 2. To provide a contemporary overview and evaluation of the current status of pepsinogen pathophysiology. 3. To modify and adapt experimental models necessary for the study of pepsinogen and acid secretion in mammalian gastric mucosa and cells. 4. To establish and validate a pepsinogen assay sensitive and reproducible enough for use in mammalian mucosa! and cellular secretory systems. 5. To delineate the fundamental (second messenger) control mechanisms (cyclic AMP and calcium calmodulin) of pepsinogen secretion in the isolated gastric gland model. 6. To define whether the process of pepsinogen secretion is independent of acid secretion in intact mucosa! preparations. 7. To identify different classes of pharmacological agents which would inhibit pepsinogen secretion and/or release. 8. To identify whether conditions present in critically ill patients liable to mucosal "stress ulceration" might influence the release of pepsinogen. DA - 1989 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1989 T1 - Control mechanisms of mammalian pepsinogen secretion TI - Control mechanisms of mammalian pepsinogen secretion UR - http://hdl.handle.net/11427/27173 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/27173
dc.identifier.vancouvercitationModlin IM. Control mechanisms of mammalian pepsinogen secretion. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Surgical Gastroenterology, 1989 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/27173en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Surgical Gastroenterologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPepsinogenen_ZA
dc.subject.otherDigestive System - Physiopathologyen_ZA
dc.subject.otherPepsinogen - secretionen_ZA
dc.titleControl mechanisms of mammalian pepsinogen secretionen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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