The role of extracellular loop three of the human gonadotropin releasing hormone receptor in ligand selectivity

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dc.contributor.advisorMillar, Roberten_ZA
dc.contributor.authorFromme, Bernhard Johannesen_ZA
dc.date.accessioned2014-07-28T14:54:56Z
dc.date.available2014-07-28T14:54:56Z
dc.date.issued2001en_ZA
dc.descriptionBibliography: leaves 123-146.
dc.description.abstractThe hypothalamic neuropeptide, gonadotropin releasing hormone (GnRH) perferentially inteacts with GnRH type I receptors on the gonadotropes in the anterior pituitary. Activation of the GnRH receptor is required for the biosynthesis and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH), which regulate reproductive function. Multiple forms of GnRH are present in most vertebrate species and are thought to have physiological functions in addition to regulating pituitary hormone release. The mammalian type I GnRH receptor is proposed to discriminate between endogenous forms of GnRH (King and Millar, 1995). In this thesis the mechanism of the GnRH selectivity by a mammalian type I GnRH receptor is examined at molecular level and previous hypotheses are re-evaluated.en_ZA
dc.identifier.apacitationFromme, B. J. (2001). <i>The role of extracellular loop three of the human gonadotropin releasing hormone receptor in ligand selectivity</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry. Retrieved from http://hdl.handle.net/11427/3129en_ZA
dc.identifier.chicagocitationFromme, Bernhard Johannes. <i>"The role of extracellular loop three of the human gonadotropin releasing hormone receptor in ligand selectivity."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2001. http://hdl.handle.net/11427/3129en_ZA
dc.identifier.citationFromme, B. 2001. The role of extracellular loop three of the human gonadotropin releasing hormone receptor in ligand selectivity. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Fromme, Bernhard Johannes AB - The hypothalamic neuropeptide, gonadotropin releasing hormone (GnRH) perferentially inteacts with GnRH type I receptors on the gonadotropes in the anterior pituitary. Activation of the GnRH receptor is required for the biosynthesis and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH), which regulate reproductive function. Multiple forms of GnRH are present in most vertebrate species and are thought to have physiological functions in addition to regulating pituitary hormone release. The mammalian type I GnRH receptor is proposed to discriminate between endogenous forms of GnRH (King and Millar, 1995). In this thesis the mechanism of the GnRH selectivity by a mammalian type I GnRH receptor is examined at molecular level and previous hypotheses are re-evaluated. DA - 2001 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2001 T1 - The role of extracellular loop three of the human gonadotropin releasing hormone receptor in ligand selectivity TI - The role of extracellular loop three of the human gonadotropin releasing hormone receptor in ligand selectivity UR - http://hdl.handle.net/11427/3129 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3129
dc.identifier.vancouvercitationFromme BJ. The role of extracellular loop three of the human gonadotropin releasing hormone receptor in ligand selectivity. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2001 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3129en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Medical Biochemistryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Biochemistryen_ZA
dc.titleThe role of extracellular loop three of the human gonadotropin releasing hormone receptor in ligand selectivityen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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