Antiplasmodial and cytotoxic activity of isolated sesquiterpene lactones from the acetone leaf extract of vernonia colorata

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dc.contributor.authorChukwujekwu, J. C.
dc.contributor.authorLategan, C. A.
dc.contributor.authorSmith, P. J.
dc.contributor.authorVan Heerden, F. R.
dc.contributor.authorVan Staden, J.
dc.date.accessioned2018-10-02T08:28:02Z
dc.date.available2018-10-02T08:28:02Z
dc.date.issued2009
dc.date.updated2016-01-14T09:06:38Z
dc.description.abstractVernonia colorata is used throughout Africa to treat various ailments. Its antiplasmodial activity has been widely reported. Using bioassay-guided fractionation, we isolated two antiplasmodial compounds — vernolide (IC50 = 1.87 μg/ml) and vernodalin (IC50 = 0.52 μg/ml) with selective indices of 1.02 and 2.79 for vernolide and vernodalin respectively. These compounds are non-specific towards parasites.
dc.identifierhttp://dx.doi.org/10.1016/j.sajb.2008.10.001
dc.identifier.apacitationChukwujekwu, J. C., Lategan, C. A., Smith, P. J., Van Heerden, F. R., & Van Staden, J. (2009). Antiplasmodial and cytotoxic activity of isolated sesquiterpene lactones from the acetone leaf extract of vernonia colorata. <i>South African Journal of Botany</i>, http://hdl.handle.net/11427/28895en_ZA
dc.identifier.chicagocitationChukwujekwu, J. C., C. A. Lategan, P. J. Smith, F. R. Van Heerden, and J. Van Staden "Antiplasmodial and cytotoxic activity of isolated sesquiterpene lactones from the acetone leaf extract of vernonia colorata." <i>South African Journal of Botany</i> (2009) http://hdl.handle.net/11427/28895en_ZA
dc.identifier.citationChukwujekwu, J. C., Lategan, C. A., Smith, P. J., Van Heerden, F. R., & Van Staden, J. (2009). Antiplasmodial and cytotoxic activity of isolated sesquiterpene lactones from the acetone leaf extract of Vernonia colorata. South African Journal of Botany, 75(1), 176-179.
dc.identifier.ris TY - AU - Chukwujekwu, J. C. AU - Lategan, C. A. AU - Smith, P. J. AU - Van Heerden, F. R. AU - Van Staden, J. AB - Vernonia colorata is used throughout Africa to treat various ailments. Its antiplasmodial activity has been widely reported. Using bioassay-guided fractionation, we isolated two antiplasmodial compounds — vernolide (IC50 = 1.87 μg/ml) and vernodalin (IC50 = 0.52 μg/ml) with selective indices of 1.02 and 2.79 for vernolide and vernodalin respectively. These compounds are non-specific towards parasites. DA - 2009 DB - OpenUCT DP - University of Cape Town J1 - South African Journal of Botany LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - Antiplasmodial and cytotoxic activity of isolated sesquiterpene lactones from the acetone leaf extract of vernonia colorata TI - Antiplasmodial and cytotoxic activity of isolated sesquiterpene lactones from the acetone leaf extract of vernonia colorata UR - http://hdl.handle.net/11427/28895 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/28895
dc.identifier.vancouvercitationChukwujekwu J C, Lategan C A, Smith P J, Van Heerden F R, Van Staden J. Antiplasmodial and cytotoxic activity of isolated sesquiterpene lactones from the acetone leaf extract of vernonia colorata. South African Journal of Botany. 2009; http://hdl.handle.net/11427/28895.en_ZA
dc.language.isoeng
dc.publisher.departmentMedicine
dc.publisher.facultyFaculty of Health Sciences
dc.publisher.institutionUniversity of Cape Town
dc.sourceSouth African Journal of Botany
dc.source.urihttp://www.sciencedirect.com/science/article/pii/S0254629908003074
dc.subject.otherAntiplasmodial
dc.subject.otherCytotoxicity
dc.subject.otherVernodalin
dc.subject.otherVernolide
dc.subject.otherVernonia colorata
dc.titleAntiplasmodial and cytotoxic activity of isolated sesquiterpene lactones from the acetone leaf extract of vernonia colorata
dc.typeJournal Article
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uct.type.filetypeText
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