Antiplasmodial and cytotoxic activity of isolated sesquiterpene lactones from the acetone leaf extract of vernonia colorata

Journal Article

2009

Permanent link to this Item
http://hdl.handle.net/11427/28895
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Chukwujekwu_Antiplasmodialcytotoxic_2009.pdf (177.87 KB)
Authors
Chukwujekwu, J. C.
Lategan, C. A.
Smith, P. J.
Van Heerden, F. R.
Van Staden, J.
Journal Title

South African Journal of Botany

Link to Journal
http://www.sciencedirect.com/science/article/pii/S0254629908003074
Journal ISSN
Volume Title
Publisher
Publisher

University of Cape Town

Department
Medicine
Faculty
Faculty of Health Sciences
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Abstract
Vernonia colorata is used throughout Africa to treat various ailments. Its antiplasmodial activity has been widely reported. Using bioassay-guided fractionation, we isolated two antiplasmodial compounds — vernolide (IC50 = 1.87 μg/ml) and vernodalin (IC50 = 0.52 μg/ml) with selective indices of 1.02 and 2.79 for vernolide and vernodalin respectively. These compounds are non-specific towards parasites.
Description
Keywords
Antiplasmodial
Cytotoxicity
Vernodalin
Vernolide
Vernonia colorata

Reference:

Chukwujekwu, J. C., Lategan, C. A., Smith, P. J., Van Heerden, F. R., & Van Staden, J. (2009). Antiplasmodial and cytotoxic activity of isolated sesquiterpene lactones from the acetone leaf extract of Vernonia colorata. South African Journal of Botany, 75(1), 176-179.

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