Investigating brain metabolite levels in adolescents living with HIV using atlas-based magnetic resonance spectroscopic imaging (MRSI)

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dc.contributor.advisorRobertson, Frances
dc.contributor.advisorMeintjes, Ernesta
dc.contributor.authorMaharaj, Sonam
dc.date.accessioned2025-02-27T10:57:12Z
dc.date.available2025-02-27T10:57:12Z
dc.date.issued2024
dc.date.updated2025-02-27T10:52:21Z
dc.description.abstractDeficiencies in brain function and structure have been linked to perinatally acquired HIV (PHIV) despite the introduction of antiretroviral therapy (ART). Current studies are predominantly based on single voxel magnetic resonance spectroscopy (MRS) in younger children, with inconsistent findings. We aimed to develop atlas-based pipelines for analysing MRSI data to examine whether there are differences in brain metabolite levels between adolescents with PHIV and uninfected controls. The study participants were 165 adolescents, of whom 86 were adolescents living with HIV from the CHER trial and 79 were age- and sociodemographically- matched uninfected controls. They were scanned on a Siemens 3T Skyra scanner with the scanning protocol including a high-resolution T1- weighted structural MRI using a multi-echo magnetization-prepared rapid acquisition gradient echo (MEMPRAGE) sequence and volumetric MRSI using spiral-encoded localized adiabatic selective refocusing (LASER) CSI. LCModel was utilized to achieve spec
dc.identifier.apacitationMaharaj, S. (2024). <i>Investigating brain metabolite levels in adolescents living with HIV using atlas-based magnetic resonance spectroscopic imaging (MRSI)</i>. (). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/41032en_ZA
dc.identifier.chicagocitationMaharaj, Sonam. <i>"Investigating brain metabolite levels in adolescents living with HIV using atlas-based magnetic resonance spectroscopic imaging (MRSI)."</i> ., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2024. http://hdl.handle.net/11427/41032en_ZA
dc.identifier.citationMaharaj, S. 2024. Investigating brain metabolite levels in adolescents living with HIV using atlas-based magnetic resonance spectroscopic imaging (MRSI). . University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. http://hdl.handle.net/11427/41032en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Maharaj, Sonam AB - Deficiencies in brain function and structure have been linked to perinatally acquired HIV (PHIV) despite the introduction of antiretroviral therapy (ART). Current studies are predominantly based on single voxel magnetic resonance spectroscopy (MRS) in younger children, with inconsistent findings. We aimed to develop atlas-based pipelines for analysing MRSI data to examine whether there are differences in brain metabolite levels between adolescents with PHIV and uninfected controls. The study participants were 165 adolescents, of whom 86 were adolescents living with HIV from the CHER trial and 79 were age- and sociodemographically- matched uninfected controls. They were scanned on a Siemens 3T Skyra scanner with the scanning protocol including a high-resolution T1- weighted structural MRI using a multi-echo magnetization-prepared rapid acquisition gradient echo (MEMPRAGE) sequence and volumetric MRSI using spiral-encoded localized adiabatic selective refocusing (LASER) CSI. LCModel was utilized to achieve spec DA - 2024 DB - OpenUCT DP - University of Cape Town KW - HIV KW - magnetic resonance spectroscopic imaging KW - MRSI LK - https://open.uct.ac.za PB - University of Cape Town PY - 2024 T1 - Investigating brain metabolite levels in adolescents living with HIV using atlas-based magnetic resonance spectroscopic imaging (MRSI) TI - Investigating brain metabolite levels in adolescents living with HIV using atlas-based magnetic resonance spectroscopic imaging (MRSI) UR - http://hdl.handle.net/11427/41032 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/41032
dc.identifier.vancouvercitationMaharaj S. Investigating brain metabolite levels in adolescents living with HIV using atlas-based magnetic resonance spectroscopic imaging (MRSI). []. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2024 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/41032en_ZA
dc.language.isoen
dc.language.rfc3066eng
dc.publisher.departmentDepartment of Human Biology
dc.publisher.facultyFaculty of Health Sciences
dc.publisher.institutionUniversity of Cape Town
dc.subjectHIV
dc.subjectmagnetic resonance spectroscopic imaging
dc.subjectMRSI
dc.titleInvestigating brain metabolite levels in adolescents living with HIV using atlas-based magnetic resonance spectroscopic imaging (MRSI)
dc.typeThesis / Dissertation
dc.type.qualificationlevelMasters
dc.type.qualificationlevelMSc
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