Determinants of innate immune responses to mycobacteria

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dc.contributor.advisorHanekom, Willem Aen_ZA
dc.contributor.advisorScriba, Thomas Jen_ZA
dc.contributor.authorShey, Muki Shehuen_ZA
dc.date.accessioned2015-01-02T09:17:07Z
dc.date.available2015-01-02T09:17:07Z
dc.date.issued2012en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractInnate cells such as macrophages, monocytes, myeloid dendritic cells and granulocytes recognise mycobacteria and initiate immune responses such as phagocytosis, cytokine production and expression of maturation markers. The type and magnitude of innate responses to mycobacteria may determine the subsequent adaptive responses generated. Our aims were to determine maturational changes in innate immune responses to mycobacteria over the first 9 months of life, and to assess effects of genetic variations in toll-like receptors on host responses to mycobacteria. This knowledge is important for designing rational strategies for vaccination against tuberculosis.en_ZA
dc.identifier.apacitationShey, M. S. (2012). <i>Determinants of innate immune responses to mycobacteria</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health. Retrieved from http://hdl.handle.net/11427/10986en_ZA
dc.identifier.chicagocitationShey, Muki Shehu. <i>"Determinants of innate immune responses to mycobacteria."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2012. http://hdl.handle.net/11427/10986en_ZA
dc.identifier.citationShey, M. 2012. Determinants of innate immune responses to mycobacteria. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Shey, Muki Shehu AB - Innate cells such as macrophages, monocytes, myeloid dendritic cells and granulocytes recognise mycobacteria and initiate immune responses such as phagocytosis, cytokine production and expression of maturation markers. The type and magnitude of innate responses to mycobacteria may determine the subsequent adaptive responses generated. Our aims were to determine maturational changes in innate immune responses to mycobacteria over the first 9 months of life, and to assess effects of genetic variations in toll-like receptors on host responses to mycobacteria. This knowledge is important for designing rational strategies for vaccination against tuberculosis. DA - 2012 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - Determinants of innate immune responses to mycobacteria TI - Determinants of innate immune responses to mycobacteria UR - http://hdl.handle.net/11427/10986 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/10986
dc.identifier.vancouvercitationShey MS. Determinants of innate immune responses to mycobacteria. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2012 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/10986en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Paediatrics and Child Healthen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChild and Adolescent Healthen_ZA
dc.titleDeterminants of innate immune responses to mycobacteriaen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePh Den_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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