Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women

dc.contributor.advisorGoedecke, Juliaen_ZA
dc.contributor.advisorCollins, Malcolmen_ZA
dc.contributor.advisorVan der Merwe, Lizeen_ZA
dc.contributor.authorJoffe, Yaelen_ZA
dc.date.accessioned2014-07-28T18:16:55Z
dc.date.available2014-07-28T18:16:55Z
dc.date.issued2013en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references.
dc.description.abstractThe primary aim of the thesis was to investigate associations between TNFA (TNFA-308 G>A and -238 G>A) and IL-6 (-174 G>C, IVS3+281 G>T, IVS4+869 A>G) sequence variants and obesity and serum lipid concentrations in black and white SA women. This included identifying sequence variants in the IL-6 gene with a reported high heterozygosity in both the white and black SA populations (rs1554606 and sr2069845). Dietary intake data of adequate reporters was then included in the analysis to investigate whether dietary fatty acid intake modulated the interactions between the TNFA and IL-6 SNPs (TNFA -308 G>A and -238 G>A & IL-6 -174 G>C, IVS3+281 G>T, IVS4+869 A>G) and obesity, measures of adiposity and serum lipid concentrations, and whether interactions identified differed between black and white women.en_ZA
dc.identifier.apacitationJoffe, Y. (2013). <i>Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/3253en_ZA
dc.identifier.chicagocitationJoffe, Yael. <i>"Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2013. http://hdl.handle.net/11427/3253en_ZA
dc.identifier.citationJoffe, Y. 2013. Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Joffe, Yael AB - The primary aim of the thesis was to investigate associations between TNFA (TNFA-308 G>A and -238 G>A) and IL-6 (-174 G>C, IVS3+281 G>T, IVS4+869 A>G) sequence variants and obesity and serum lipid concentrations in black and white SA women. This included identifying sequence variants in the IL-6 gene with a reported high heterozygosity in both the white and black SA populations (rs1554606 and sr2069845). Dietary intake data of adequate reporters was then included in the analysis to investigate whether dietary fatty acid intake modulated the interactions between the TNFA and IL-6 SNPs (TNFA -308 G>A and -238 G>A & IL-6 -174 G>C, IVS3+281 G>T, IVS4+869 A>G) and obesity, measures of adiposity and serum lipid concentrations, and whether interactions identified differed between black and white women. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women TI - Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women UR - http://hdl.handle.net/11427/3253 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3253
dc.identifier.vancouvercitationJoffe Y. Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3253en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Human Biologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherHuman Biologyen_ZA
dc.titleDietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican womenen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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