Integration of In Silico and In Vitro ADMET properties in lead identification and optimization of compounds for the treatment of parasitic diseases

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dc.contributor.advisorChibale, Kellyen_ZA
dc.contributor.advisorMasimirembwa, Collenen_ZA
dc.contributor.advisorSmith, Peteren_ZA
dc.contributor.authorThelingwani, Roslynen_ZA
dc.date.accessioned2014-09-02T18:13:51Z
dc.date.available2014-09-02T18:13:51Z
dc.date.issued2012en_ZA
dc.description.abstractParasitic infections are the major causes of illness and death in tropical regions especially in Africa. The main parasitic diseases include leishmaniasis, filariasis, malaria, river blindness, Chagas disease and schistosomiasis. With the absence of vaccines, treatment relies mainly on chemotherapy hence the need for efficacious and safe medicines. Many of the medicines currently used have low efficacy and cause side effects. Some are also being lost to drug resistance. To address the inadequacy of treatment options for infectious diseases, a number of initiatives have been started to promote drug discovery and development in Africa. In parallel they have been collaboration between African institutions and leading pharmaceutical companies as well as other relevant R & D organizations. This has led to the need to modernize African approaches to drug discovery and development with respect to the integration of medicinal chemistry, pharmacology and pharmacokinetics as reflected in the processes of Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET). However, scientific and technological expertise in pharmacokinetics for drug discovery is under developed in Africa.en_ZA
dc.identifier.apacitationThelingwani, R. (2012). <i>Integration of In Silico and In Vitro ADMET properties in lead identification and optimization of compounds for the treatment of parasitic diseases</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/6889en_ZA
dc.identifier.chicagocitationThelingwani, Roslyn. <i>"Integration of In Silico and In Vitro ADMET properties in lead identification and optimization of compounds for the treatment of parasitic diseases."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2012. http://hdl.handle.net/11427/6889en_ZA
dc.identifier.citationThelingwani, R. 2012. Integration of In Silico and In Vitro ADMET properties in lead identification and optimization of compounds for the treatment of parasitic diseases. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Thelingwani, Roslyn AB - Parasitic infections are the major causes of illness and death in tropical regions especially in Africa. The main parasitic diseases include leishmaniasis, filariasis, malaria, river blindness, Chagas disease and schistosomiasis. With the absence of vaccines, treatment relies mainly on chemotherapy hence the need for efficacious and safe medicines. Many of the medicines currently used have low efficacy and cause side effects. Some are also being lost to drug resistance. To address the inadequacy of treatment options for infectious diseases, a number of initiatives have been started to promote drug discovery and development in Africa. In parallel they have been collaboration between African institutions and leading pharmaceutical companies as well as other relevant R & D organizations. This has led to the need to modernize African approaches to drug discovery and development with respect to the integration of medicinal chemistry, pharmacology and pharmacokinetics as reflected in the processes of Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET). However, scientific and technological expertise in pharmacokinetics for drug discovery is under developed in Africa. DA - 2012 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - Integration of In Silico and In Vitro ADMET properties in lead identification and optimization of compounds for the treatment of parasitic diseases TI - Integration of In Silico and In Vitro ADMET properties in lead identification and optimization of compounds for the treatment of parasitic diseases UR - http://hdl.handle.net/11427/6889 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/6889
dc.identifier.vancouvercitationThelingwani R. Integration of In Silico and In Vitro ADMET properties in lead identification and optimization of compounds for the treatment of parasitic diseases. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2012 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6889en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.titleIntegration of In Silico and In Vitro ADMET properties in lead identification and optimization of compounds for the treatment of parasitic diseasesen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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