The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer

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dc.contributor.advisorPrince, Sharonen_ZA
dc.contributor.authorDavis, Emilyen_ZA
dc.date.accessioned2015-01-10T06:48:15Z
dc.date.available2015-01-10T06:48:15Z
dc.date.issued2009en_ZA
dc.descriptionIncludes abstract.en_ZA
dc.descriptionIncludes bibliographical references (leaves 102-131).en_ZA
dc.description.abstractT-box factors play crucial roles in embryogenesis and mutations in T-box factor genes have been implicated in multiple human disorders. In addition, an increasing body of evidence implicates the T-box family in cell cycle regulation and in cancer...The aim of this study was therefore to address this question by establishing TBX2 over-expression and knockdown cell culture models. The results show that TBX2 does indeed contribute directly to the oncogenic process and further reveals a novel mechanism by which it contributes to tumourigenesis.en_ZA
dc.identifier.apacitationDavis, E. (2009). <i>The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/11890en_ZA
dc.identifier.chicagocitationDavis, Emily. <i>"The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2009. http://hdl.handle.net/11427/11890en_ZA
dc.identifier.citationDavis, E. 2009. The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Davis, Emily AB - T-box factors play crucial roles in embryogenesis and mutations in T-box factor genes have been implicated in multiple human disorders. In addition, an increasing body of evidence implicates the T-box family in cell cycle regulation and in cancer...The aim of this study was therefore to address this question by establishing TBX2 over-expression and knockdown cell culture models. The results show that TBX2 does indeed contribute directly to the oncogenic process and further reveals a novel mechanism by which it contributes to tumourigenesis. DA - 2009 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer TI - The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer UR - http://hdl.handle.net/11427/11890 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/11890
dc.identifier.vancouvercitationDavis E. The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2009 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/11890en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Human Biologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherHuman Biologyen_ZA
dc.titleThe role of the developmentally important transcription factor, TBX2, in the cell cycle and canceren_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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