Cellular immunity of naïve and BCG vaccinated neonates

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dc.contributor.advisorKaplan, Gillaen_ZA
dc.contributor.authorWatkins, Marcia Linda Vivienneen_ZA
dc.date.accessioned2015-01-02T09:16:34Z
dc.date.available2015-01-02T09:16:34Z
dc.date.issued2010en_ZA
dc.descriptionIncludes abstract.en_ZA
dc.descriptionIncludes bibliographical references (leaves 153-187).en_ZA
dc.description.abstractDespite more than 95% vaccination coverage with Mycobacterium bovis Bacille Calmette-Guérin (BCG), tuberculosis (TB) remains epidemic in South Africa. The dichotomy that successful pregnancy is usually associated with a type 2 (Th2) cytokine profile in the newborn child, whereas immunity to Mycobacterium tuberculosis (Mtb) is associated with the development of a type 1 helper (Th1) cytokine response, could impact on the subsequent adaptive immune response to BCG vaccination. Previous studies have suggested that immune responses in early life may be defective and related to the immaturity of antigen-presenting cells and/or T cells.en_ZA
dc.identifier.apacitationWatkins, M. L. V. (2010). <i>Cellular immunity of naïve and BCG vaccinated neonates</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/10984en_ZA
dc.identifier.chicagocitationWatkins, Marcia Linda Vivienne. <i>"Cellular immunity of naïve and BCG vaccinated neonates."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2010. http://hdl.handle.net/11427/10984en_ZA
dc.identifier.citationWatkins, M. 2010. Cellular immunity of naïve and BCG vaccinated neonates. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Watkins, Marcia Linda Vivienne AB - Despite more than 95% vaccination coverage with Mycobacterium bovis Bacille Calmette-Guérin (BCG), tuberculosis (TB) remains epidemic in South Africa. The dichotomy that successful pregnancy is usually associated with a type 2 (Th2) cytokine profile in the newborn child, whereas immunity to Mycobacterium tuberculosis (Mtb) is associated with the development of a type 1 helper (Th1) cytokine response, could impact on the subsequent adaptive immune response to BCG vaccination. Previous studies have suggested that immune responses in early life may be defective and related to the immaturity of antigen-presenting cells and/or T cells. DA - 2010 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - Cellular immunity of naïve and BCG vaccinated neonates TI - Cellular immunity of naïve and BCG vaccinated neonates UR - http://hdl.handle.net/11427/10984 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/10984
dc.identifier.vancouvercitationWatkins MLV. Cellular immunity of naïve and BCG vaccinated neonates. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2010 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/10984en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleCellular immunity of naïve and BCG vaccinated neonatesen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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