The Emergence of Embryonic Myosin Heavy Chain during Branchiomeric Muscle Development

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dc.contributor.authorYahya, Imadeldin
dc.contributor.authorBöing, Marion
dc.contributor.authorHockman, Dorit
dc.contributor.authorBrand-Saberi, Beate
dc.contributor.authorMorosan-Puopolo, Gabriela
dc.date.accessioned2022-09-13T14:12:35Z
dc.date.available2022-09-13T14:12:35Z
dc.date.issued2022-05-25
dc.date.updated2022-06-23T12:11:34Z
dc.description.abstractA prerequisite for discovering the properties and therapeutic potential of branchiomeric muscles is an understanding of their fate determination, pattering and differentiation. Although the expression of differentiation markers such as myosin heavy chain (MyHC) during trunk myogenesis has been more intensively studied, little is known about its expression in the developing branchiomeric muscle anlagen. To shed light on this, we traced the onset of MyHC expression in the facial and neck muscle anlagen by using the whole-mount in situ hybridization between embryonic days E9.5 and E15.5 in the mouse. Unlike trunk muscle, the facial and neck muscle anlagen express MyHC at late stages. Within the branchiomeric muscles, our results showed variation in the emergence of MyHC expression. MyHC was first detected in the first arch-derived muscle anlagen, while its expression in the second arch-derived muscle and non-somitic neck muscle began at a later time point. Additionally, we show that non-ectomesenchymal neural crest invasion of the second branchial arch is delayed compared with that of the first brachial arch in chicken embryos. Thus, our findings reflect the timing underlying branchiomeric muscle differentiation.en_US
dc.identifierdoi: 10.3390/life12060785
dc.identifier.apacitationYahya, I., Böing, M., Hockman, D., Brand-Saberi, B., & Morosan-Puopolo, G. (2022). The Emergence of Embryonic Myosin Heavy Chain during Branchiomeric Muscle Development. <i>Life</i>, 12(6), 785. http://hdl.handle.net/11427/36807en_ZA
dc.identifier.chicagocitationYahya, Imadeldin, Marion Böing, Dorit Hockman, Beate Brand-Saberi, and Gabriela Morosan-Puopolo "The Emergence of Embryonic Myosin Heavy Chain during Branchiomeric Muscle Development." <i>Life</i> 12, 6. (2022): 785. http://hdl.handle.net/11427/36807en_ZA
dc.identifier.citationYahya, I., Böing, M., Hockman, D., Brand-Saberi, B. & Morosan-Puopolo, G. 2022. The Emergence of Embryonic Myosin Heavy Chain during Branchiomeric Muscle Development. <i>Life.</i> 12(6):785. http://hdl.handle.net/11427/36807en_ZA
dc.identifier.ris TY - Journal Article AU - Yahya, Imadeldin AU - Böing, Marion AU - Hockman, Dorit AU - Brand-Saberi, Beate AU - Morosan-Puopolo, Gabriela AB - A prerequisite for discovering the properties and therapeutic potential of branchiomeric muscles is an understanding of their fate determination, pattering and differentiation. Although the expression of differentiation markers such as myosin heavy chain (MyHC) during trunk myogenesis has been more intensively studied, little is known about its expression in the developing branchiomeric muscle anlagen. To shed light on this, we traced the onset of MyHC expression in the facial and neck muscle anlagen by using the whole-mount in situ hybridization between embryonic days E9.5 and E15.5 in the mouse. Unlike trunk muscle, the facial and neck muscle anlagen express MyHC at late stages. Within the branchiomeric muscles, our results showed variation in the emergence of MyHC expression. MyHC was first detected in the first arch-derived muscle anlagen, while its expression in the second arch-derived muscle and non-somitic neck muscle began at a later time point. Additionally, we show that non-ectomesenchymal neural crest invasion of the second branchial arch is delayed compared with that of the first brachial arch in chicken embryos. Thus, our findings reflect the timing underlying branchiomeric muscle differentiation. DA - 2022-05-25 DB - OpenUCT DP - University of Cape Town IS - 6 J1 - Life LK - https://open.uct.ac.za PY - 2022 T1 - The Emergence of Embryonic Myosin Heavy Chain during Branchiomeric Muscle Development TI - The Emergence of Embryonic Myosin Heavy Chain during Branchiomeric Muscle Development UR - http://hdl.handle.net/11427/36807 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/36807
dc.identifier.vancouvercitationYahya I, Böing M, Hockman D, Brand-Saberi B, Morosan-Puopolo G. The Emergence of Embryonic Myosin Heavy Chain during Branchiomeric Muscle Development. Life. 2022;12(6):785. http://hdl.handle.net/11427/36807.en_ZA
dc.language.isoenen_US
dc.publisher.departmentDivision of Cell Biologyen_US
dc.publisher.facultyFaculty of Health Sciencesen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceLifeen_US
dc.source.journalissue6en_US
dc.source.journalvolume12en_US
dc.source.pagination785en_US
dc.source.urihttps://www.mdpi.com/journal/life
dc.titleThe Emergence of Embryonic Myosin Heavy Chain during Branchiomeric Muscle Developmenten_US
dc.typeJournal Articleen_US
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