The Emergence of Embryonic Myosin Heavy Chain during Branchiomeric Muscle Development
Journal Article
2022-05-25
Permanent link to this Item
Authors
Journal Title
Life
Link to Journal
Journal ISSN
Volume Title
Publisher
Publisher
Department
Faculty
Series
Abstract
A prerequisite for discovering the properties and therapeutic potential of branchiomeric muscles is an understanding of their fate determination, pattering and differentiation. Although the expression of differentiation markers such as myosin heavy chain (MyHC) during trunk myogenesis has been more intensively studied, little is known about its expression in the developing branchiomeric muscle anlagen. To shed light on this, we traced the onset of MyHC expression in the facial and neck muscle anlagen by using the whole-mount in situ hybridization between embryonic days E9.5 and E15.5 in the mouse. Unlike trunk muscle, the facial and neck muscle anlagen express MyHC at late stages. Within the branchiomeric muscles, our results showed variation in the emergence of MyHC expression. MyHC was first detected in the first arch-derived muscle anlagen, while its expression in the second arch-derived muscle and non-somitic neck muscle began at a later time point. Additionally, we show that non-ectomesenchymal neural crest invasion of the second branchial arch is delayed compared with that of the first brachial arch in chicken embryos. Thus, our findings reflect the timing underlying branchiomeric muscle differentiation.
Description
Reference:
Yahya, I., Böing, M., Hockman, D., Brand-Saberi, B. & Morosan-Puopolo, G. 2022. The Emergence of Embryonic Myosin Heavy Chain during Branchiomeric Muscle Development. Life. 12(6):785. http://hdl.handle.net/11427/36807