An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds

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dc.contributor.advisorParker, Iqbalen_ZA
dc.contributor.advisorKaschula, Catherine Harten_ZA
dc.contributor.authorSmith, Muneerahen_ZA
dc.date.accessioned2015-05-13T14:19:00Z
dc.date.available2015-05-13T14:19:00Z
dc.date.issued2014en_ZA
dc.descriptionIncludes abstract.~Includes bibliographical references.en_ZA
dc.description.abstractCrushed garlic contains organosulfur compounds (OSC), which are reported to have cancer chemotherapeutic properties both in vitro and in vivo. A library of 15 organosulfur analogues were obtained as mechanistic probes in WHCO1 oesophageal cancer cells. Structure-activity studies showed a positive correlation between the anti-proliferative-IC50 of disulfides and the relative stability of their anion leaving groups, as assessed through resonance and quantified by predictive pKa-values.en_ZA
dc.identifier.apacitationSmith, M. (2014). <i>An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry. Retrieved from http://hdl.handle.net/11427/12795en_ZA
dc.identifier.chicagocitationSmith, Muneerah. <i>"An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2014. http://hdl.handle.net/11427/12795en_ZA
dc.identifier.citationSmith, M. 2014. An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Smith, Muneerah AB - Crushed garlic contains organosulfur compounds (OSC), which are reported to have cancer chemotherapeutic properties both in vitro and in vivo. A library of 15 organosulfur analogues were obtained as mechanistic probes in WHCO1 oesophageal cancer cells. Structure-activity studies showed a positive correlation between the anti-proliferative-IC50 of disulfides and the relative stability of their anion leaving groups, as assessed through resonance and quantified by predictive pKa-values. DA - 2014 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds TI - An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds UR - http://hdl.handle.net/11427/12795 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/12795
dc.identifier.vancouvercitationSmith M. An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2014 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12795en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Medical Biochemistryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Biochemistryen_ZA
dc.titleAn investigation into the anti-cancer mechanism of garlic-related organosulfur compoundsen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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