An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds

Master Thesis

2014

Permanent link to this Item
http://hdl.handle.net/11427/12795
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thesis_hsf_2014_smith_m.pdf (3.6 MB)
Authors
Smith, Muneerah
Supervisors
Parker, Iqbal
Kaschula, Catherine Hart
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University of Cape Town

Department
Division of Medical Biochemistry
Faculty
Faculty of Health Sciences
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Abstract
Crushed garlic contains organosulfur compounds (OSC), which are reported to have cancer chemotherapeutic properties both in vitro and in vivo. A library of 15 organosulfur analogues were obtained as mechanistic probes in WHCO1 oesophageal cancer cells. Structure-activity studies showed a positive correlation between the anti-proliferative-IC50 of disulfides and the relative stability of their anion leaving groups, as assessed through resonance and quantified by predictive pKa-values.
Description

Includes abstract.~Includes bibliographical references.

Keywords
Medical Biochemistry

Reference:

Smith, M. 2014. An investigation into the anti-cancer mechanism of garlic-related organosulfur compounds. University of Cape Town.

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