The effect of muscle glycogen status on control of substrate metabolism during exercise

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dc.contributor.advisorNoakes, Timothy Den_ZA
dc.contributor.advisorDennis, Steveen_ZA
dc.contributor.authorWeltan, Sandra Maryen_ZA
dc.date.accessioned2017-12-12T10:55:58Z
dc.date.available2017-12-12T10:55:58Z
dc.date.issued1998en_ZA
dc.description.abstractGlycogen depletion has frequently been shown to result in a decrease in respiratory exchange ratio (RER). However, the metabolic response to glycogen depletion has generally been studied in overnight fasted subjects or in subjects who were already fatigued, or hypoglycaemic, or both, raising the question of whether the differences seen were due to general "carbohydrate deficiency" or due specifically to muscle or liver glycogen depletion. If euglycaemia and especially hyperglycaemia is maintained, the " carbohydrate deficiency" is overcome. In addition, because insulin stimulates muscle glucose uptake and not liver glucose uptake during euglycaemia (except at very high concentrations), insulin infusion would differentiate between liver and muscle glycogen depletion, since if the decrease in RER previously observed is abolished with insulin infusion while euglycaemia is maintained, this would indicate that the decrease is specifically due to muscle glycogen depletion. Thus, the aim of this study was to investigate the metabolic effect of glycogen content while an adequate amount or an excess of carbohydrate was provided in the form of an intravenous glucose infusion and when plasma insulin concentrations are raised.en_ZA
dc.identifier.apacitationWeltan, S. M. (1998). <i>The effect of muscle glycogen status on control of substrate metabolism during exercise</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,MRC/UCT RU for Exercise and Sport Medicine. Retrieved from http://hdl.handle.net/11427/26559en_ZA
dc.identifier.chicagocitationWeltan, Sandra Mary. <i>"The effect of muscle glycogen status on control of substrate metabolism during exercise."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,MRC/UCT RU for Exercise and Sport Medicine, 1998. http://hdl.handle.net/11427/26559en_ZA
dc.identifier.citationWeltan, S. 1998. The effect of muscle glycogen status on control of substrate metabolism during exercise. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Weltan, Sandra Mary AB - Glycogen depletion has frequently been shown to result in a decrease in respiratory exchange ratio (RER). However, the metabolic response to glycogen depletion has generally been studied in overnight fasted subjects or in subjects who were already fatigued, or hypoglycaemic, or both, raising the question of whether the differences seen were due to general "carbohydrate deficiency" or due specifically to muscle or liver glycogen depletion. If euglycaemia and especially hyperglycaemia is maintained, the " carbohydrate deficiency" is overcome. In addition, because insulin stimulates muscle glucose uptake and not liver glucose uptake during euglycaemia (except at very high concentrations), insulin infusion would differentiate between liver and muscle glycogen depletion, since if the decrease in RER previously observed is abolished with insulin infusion while euglycaemia is maintained, this would indicate that the decrease is specifically due to muscle glycogen depletion. Thus, the aim of this study was to investigate the metabolic effect of glycogen content while an adequate amount or an excess of carbohydrate was provided in the form of an intravenous glucose infusion and when plasma insulin concentrations are raised. DA - 1998 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1998 T1 - The effect of muscle glycogen status on control of substrate metabolism during exercise TI - The effect of muscle glycogen status on control of substrate metabolism during exercise UR - http://hdl.handle.net/11427/26559 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/26559
dc.identifier.vancouvercitationWeltan SM. The effect of muscle glycogen status on control of substrate metabolism during exercise. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,MRC/UCT RU for Exercise and Sport Medicine, 1998 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/26559en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentMRC/UCT RU for Exercise and Sport Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Physiologyen_ZA
dc.subject.otherExercise Scienceen_ZA
dc.titleThe effect of muscle glycogen status on control of substrate metabolism during exerciseen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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